ADOR2A C Allele Carriers Exhibit Ergogenic Responses to Caffeine Supplementation
Grgic J, Pickering C, Bishop DJ, Del Coso J, Schoenfeld BJ, Tinsley GM, Pedisic Z
Nutrients · 29 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-03-11 · Nutrients · vol. 12 · número 3 · pág. 741
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 49 citas · más que el 96% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Coffee research and impacts · Eating Disorders and Behaviors · Cannabis and Cannabinoid Research
- Palabras clave
- Caffeine, Allele, Endocrinology, Medicine, Internal medicine, Pharmacology, Biology, Genetics, Gene
- MeSH
- humans, caffeine, receptor, adenosine a2a, body mass index, exercise, cross-over studies, physical endurance, heterozygote, alleles, dietary supplements, adult, female, male, young adult, performance-enhancing substances, pharmacogenomic variants
7 autores
- Jozo Grgić🇦🇺 · autor de correspondenciaVictoria University
- Craig Pickering🇬🇧University of Lancashire
- David John Bishop🇦🇺Edith Cowan University; Victoria University
- Juan Del Coso🇪🇸Universidad Rey Juan Carlos
- Brad Jon Schoenfeld🇺🇸Lehman College
- Grant M. Tinsley🇺🇸Texas Tech University
- Željko Pedišić🇦🇺Victoria University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine's ergogenic effects on exercise performance are generally explained by its ability to bind to adenosine receptors. ADORA2A is the gene that encodes A2A subtypes of adenosine receptors. It has been suggested that ADORA2A gene polymorphisms may be responsible for the inter-individual variations in the effects of caffeine on exercise performance. In the only study that explored the influence of variation in ADORA2A-in this case, a common polymorphism (rs5751876)-on the ergogenic effects of caffeine on exercise performance, C allele carriers were identified as "non-responders" to caffeine. To explore if C allele carriers are true "non-responders" to the ergogenic effects of caffeine, in this randomized, double-blind study, we examined the acute effects of caffeine ingestion among a sample consisting exclusively of ADORA2A C allele carriers. Twenty resistance-trained men identified as ADORA2A C allele carriers (CC/CT genotype) were tested on two occasions, following the ingestion of caffeine (3 mg/kg) and a placebo. Exercise performance was evaluated with movement velocity, power output, and muscle endurance during the bench press exercise, countermovement jump height, and power output during a Wingate test. Out of the 25 analyzed variables, caffeine was ergogenic in 21 (effect size range: 0.14 to 0.96). In conclusion, ADORA2A (rs5751876) C allele carriers exhibited ergogenic responses to caffeine ingestion, with the magnitude of improvements similar to what was previously reported in the literature among samples that were not genotype-specific. Therefore, individuals with the CT/CC genotype may still consider supplementing with caffeine for acute improvements in performance.
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