Transcranial Photobiomodulation (tPBM) With 1,064-nm Laser to Improve Cerebral Metabolism of the Human Brain In Vivo
Pruitt T, Wang X, Wu A, Kallioniemi E, Husain MM, Liu H
Lasers in surgery and medicine · 65 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Mental Health
- Gobierno
- NIMH NIH HHS
- Subvenciones
- National Institute of Mental Health (RF1 MH114285); National Institutes of Health (1rf1mh114285-01)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-03-15 · Lasers Surg Med · vol. 52 · número 9 · págs. 807–813
- Editorial
- Wiley
- Citado
- 84 citas · más que el 96% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Dermatologic Treatments and Research · Photodynamic Therapy Research Studies
- Palabras clave
- Medicine, Transcranial magnetic stimulation, Human brain, Statistical significance, In vivo, Audiology, Stimulation, Psychology, Anesthesia, Internal medicine, Psychiatry, Biology
- MeSH
- brain, humans, spectroscopy, near-infrared, reproducibility of results, lasers, aged, child, preschool, hemodynamics
6 autores
- Tyrell Pruitt🇺🇸The University of Texas at Arlington; Southwestern Medical Center; Southwestern Medical Center; The University of Texas Southwestern Medical Center
- Xinlong Wang🇺🇸The University of Texas at Arlington
- Anqi Wu🇺🇸The University of Texas at Arlington
- Elisa Kallioniemi🇺🇸Southwestern Medical Center; Southwestern Medical Center; The University of Texas Southwestern Medical Center
- Mustafa M. Husain🇺🇸Southwestern Medical Center; Southwestern Medical Center; The University of Texas Southwestern Medical Center
- Hanli Liu🇺🇸 · autor de correspondenciaThe University of Texas at Arlington
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
In our previous proof-of-principle study, transcranial photobiomodulation (tPBM) with 1,064-nm laser was reported to significantly increase concentration changes of oxygenated hemoglobin (∆[HbO]) and oxidized-state cytochrome c oxidase (∆[oxi-CCO]) in the human brain. This paper further investigated (i) its validity in two different subsets of young human subjects at two study sites over a period of 3 years and (ii) age-related effects of tPBM by comparing sham-controlled increases of ∆[HbO] and ∆[oxi-CCO] between young and older adults.
Study design/materials and methods
We measured sham-controlled ∆[HbO] and ∆[oxi-CCO] using broadband near-infrared spectroscopy (bb-NIRS) in 15 young (26.7 ± 2.7 years of age) and 5 older (68.2 ± 4.8 years of age) healthy normal subjects before, during, and after right-forehead tPBM/sham stimulation with 1,064-nm laser. Student t tests were used to test statistical differences in tPBM-induced ∆[HbO] and ∆[oxi-CCO] (i) between the 15 young subjects and those of 11 reported previously and (ii) between the two age groups measured in this study.
Results
Statistical analysis showed that no significant difference existed in ∆[HbO] and ∆[oxi-CCO] during and post tPBM between the two subsets of young subjects at two study sites over a period of 3 years. Furthermore, the two age groups showed statistically identical net increases in sham-controlled ∆[HbO] and ∆[oxi-CCO].
Conclusions
This study provided strong evidence to validate/confirm our previous findings that tPBM with 1,064-nm laser enables to increase cerebral ∆[HbO] and ∆[oxi-CCO] in the human brain, as measured by bb-NIRS. Overall, it demonstrated the robust reproducibility of tPBM being able to improve cerebral hemodynamics and metabolism of the human brain in vivo in both young and older adults. Lasers Surg. Med. © 2020 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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