Vitamin D, magnesium, calcium, and their interaction in relation to colorectal cancer recurrence and all-cause mortality
Wesselink E, Kok DE, Bours MJL, de Wilt JHW, van Baar H, van Zutphen M, Geijsen AMJR, Keulen ETP, Hansson BME, van den Ouweland J, Witkamp RF, Weijenberg MP, Kampman E, van Duijnhoven FJB
The American journal of clinical nutrition · 41 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- World Cancer Research Fund International
- Organización sin fines de lucro
- Health Foundation Limburg
- Gobierno
- ZonMw
- Universidad u hospital
- Universiteit Maastricht
- Universidad u hospital
- Maastricht Universitair Medisch Centrum
- Organización sin fines de lucro
- KWF Kankerbestrijding
- Universidad u hospital
- Radboud Universitair Medisch Centrum
- Organización sin fines de lucro
- Wereld Kanker Onderzoek Fonds
- Universidad u hospital
- Wageningen University and Research
- Organización sin fines de lucro
- Alpe d'Huzes/Dutch Cancer Society
- Organización sin fines de lucro
- Leven met kanker” of the Dutch Cancer Society
- Gobierno
- ERA-NET on Translational Cancer Research
- Organización sin fines de lucro
- Dutch Cancer Society
- Organización sin fines de lucro
- Kankeronderzoekfonds Limburg
- Gobierno
- Netherlands Organization for Health Research and Development
- Subvenciones
- KWF Kankerbestrijding (UW2014-6877); KWF Kankerbestrijding (UW2013‐6397); World Cancer Research Fund International (2014/1179); Health Foundation Limburg (00005739)
Según 15 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-02-25 · Am J Clin Nutr · vol. 111 · número 5 · págs. 1007–1017
- Editorial
- Elsevier BV
- Citado
- 63 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Vitamin D Research Studies · Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Palabras clave
- Magnesium, Vitamin D and neurology, Medicine, Calcium, Hazard ratio, Proportional hazards model, Internal medicine, Colorectal cancer, Gastroenterology, Vitamin, Endocrinology, Population, Cancer, Chemistry, Confidence interval
- MeSH
- humans, colorectal neoplasms, neoplasm recurrence, local, calcium, magnesium, calcifediol, vitamin d, neoplasm staging, longitudinal studies, prospective studies, dietary supplements, aged, middle aged, female, male
14 autores
- Evertine Wesselink🇳🇱 · autor de correspondenciaWageningen University & Research
- Dieuwertje E. G. Kok🇳🇱Wageningen University & Research
- Martijn J.L. Bours🇳🇱Maastricht University
- Johannes H.W. de Wilt🇳🇱Radboud University Nijmegen; Radboud University Medical Center
- Harm van Baar🇳🇱Wageningen University & Research
- Moniek van Zutphen🇳🇱Wageningen University & Research
- Anne J. M. R. Geijsen🇳🇱Wageningen University & Research
- Eric T.P. Keulen🇳🇱Zuyderland Medisch Centrum
- Bibi M. E. Hansson🇳🇱Canisius-Wilhelmina Ziekenhuis
- Jody van den Ouweland🇳🇱Canisius-Wilhelmina Ziekenhuis
- Renger F. Witkamp🇳🇱Wageningen University & Research
- Matty P. Weijenberg🇳🇱Maastricht University
- Ellen Kampman🇳🇱Wageningen University & Research
- Fränzel J.B. van Duijnhoven🇳🇱Wageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Higher concentrations of 25-hydroxyvitamin D3 [25(OH)D3] at diagnosis are associated with a lower mortality risk in colorectal cancer (CRC) patients. However, magnesium and calcium are important in vitamin D metabolism.
Objectives
We aimed to investigate 25(OH)D3, magnesium, or calcium and their interaction among patients with CRC in relation to recurrence and all-cause mortality.
Methods
The study population included 1169 newly diagnosed stage I-III CRC patients from 2 prospective cohorts. Associations between 25(OH)D3 concentrations, magnesium or calcium intake through diet and/or supplements at diagnosis, and recurrence and all-cause mortality were evaluated using multivariable Cox proportional hazard models. The interaction between 25(OH)D3 and magnesium or calcium was assessed by investigating 1) joint compared with separate effects, using a single reference category; and 2) the effect estimates of 1 factor across strata of another.
Results
Serum 25(OH)D3, calcium, and magnesium, alone and their interactions, were not associated with recurrence. Serum 25(OH)D3 concentrations seemed to be associated with all-cause mortality. An inverse association between magnesium intake (HRQ3 vs. Q1: 0.55; 95% CI: 0.32, 0.95 and HRQ4 vs. Q1: 0.65; 95% CI: 0.35, 1.21), but not calcium intake, and all-cause mortality was observed. When investigating the interaction between 25(OH)D3 and magnesium, we observed the lowest risk of all-cause mortality in patients with sufficient vitamin D concentrations (≥50 nmol/L) and a high magnesium intake (median split) (HR: 0.53; 95% CI: 0.31, 0.89) compared with patients who were vitamin D deficient (<50 nmol/L) and had a low magnesium intake. No interactions between calcium and vitamin D in relation to all-cause mortality were observed.
Conclusions
Our findings suggest that the presence of an adequate status of 25(OH)D3 in combination with an adequate magnesium intake is essential in lowering the risk of mortality in CRC patients, yet the underlying mechanism should be studied. In addition, diet and lifestyle intervention studies are needed to confirm our findings. The COLON study was registered at clinicaltrials.gov as NCT03191110. The EnCoRe study was registered at trialregister.nl as NTR7099.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.