Association of magnesium intake with type 2 diabetes and total stroke: an updated systematic review and meta-analysis
Zhao B, Zeng L, Zhao J, Wu Q, Dong Y, Zou F, Gan L, Wei Y, Zhang W
BMJ open · 41 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Jiangxi Province
- Universidad u hospital
- Nanchang University
- Subvenciones
- National Natural Science Foundation of China (81560345); Natural Science Foundation of Jiangxi Province (20161BAB215237)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-03-01 · BMJ Open · vol. 10 · número 3 · pág. e032240
- Editorial
- BMJ
- Citado
- 82 citas · más que el 93% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 81 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Palabras clave
- Medicine, Relative risk, Meta-analysis, Stroke (engine), Cochrane Library, Internal medicine, Type 2 diabetes, Subgroup analysis, Prospective cohort study, Diabetes mellitus, Cohort study, Confidence interval, Endocrinology
- MeSH
- humans, brain ischemia, diabetes mellitus, type 2, magnesium, prospective studies, female, male, stroke
9 autores
- Binghao Zhao🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Lianli Zeng🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Jiani Zhao🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Qian Wu🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Yifei Dong🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Fang Zou🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Li Gan🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Yiping Wei🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Wenxiong Zhang🇨🇳 · autor de correspondenciaNanchang University; Second Affiliated Hospital of Nanchang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The detailed associations between type 2 diabetes (T2D) and total stroke and magnesium intake as well as the dose-response trend should be updated in a timely manner.
Design
Systematic review and meta-analyses.
Data sources
PubMed, Embase, Cochrane Library, Web of Science and ClinicalTrials.gov were rigorously searched from inception to 15 March 2019.
Eligibility criteria
Prospective cohort studies investigating these two diseases were included.
Data synthesis
Relative risk (RR) and 95% CI in random effects models as well as absolute risk (AR) were pooled to calculate the risk of T2D and stroke. Methodological quality was assessed by the Newcastle-Ottawa Scale.
Results
Forty-one studies involving 53 cohorts were included. The magnitude of the risk was significantly reduced by 22% for T2D (RR 0.78 (95% CI 0.75 to 0.81); p2 body mass index and those with ≥12-year follow-up; the reduced risk in Asians was not as notable as that in North American and European populations.
Conclusions
Magnesium intake has significantly inverse associations with T2D and total stroke in a dose-dependent manner. Feasible magnesium-rich dietary patterns may be highly beneficial for specific populations and could be highlighted in the primary T2D and total stroke prevention strategies disseminated to the public.
Prospero registration number
CRD42018092690.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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