Consumption of the Fish Oil High-Fat Diet Uncouples Obesity and Mammary Tumor Growth through Induction of Reactive Oxygen Species in Protumor Macrophages
Liu L, Liu L, Jin R, Hao J, Zeng J, Yin D, Yi Y, Zhu M, Mandal A, Hua Y, Ng CK, Egilmez NK, Sauter ER, Li B
Cancer research · 98 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Gobierno
- NIH
- Gobierno
- NCI NIH HHS
- Gobierno
- NIAID NIH HHS
- Subvenciones
- National Cancer Institute (R01 CA177679); National Institute of Allergy and Infectious Diseases (R01 AI137324); National Cancer Institute (R01 CA180986); National Institutes of Health (R01CA177679); National Institutes of Health (R01CA180986); National Institutes of Health (R01AI137324)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2020-03-25 · Cancer Res · vol. 80 · número 12 · págs. 2564–2574
- Editorial
- American Association for Cancer Research
- Citado
- 126 citas · más que el 94% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Peroxisome Proliferator-Activated Receptors · Cancer, Lipids, and Metabolism · Fatty Acid Research and Health
- Palabras clave
- Fish oil, Mammary tumor, Biology, Reactive oxygen species, Obesity, Macrophage, Cancer, Adipose tissue, Internal medicine, Physiology, Endocrinology, Immunology, Breast cancer, Medicine, Biochemistry, Fish <Actinopterygii>, In vitro
- MeSH
- mammary glands, animal, cell line, tumor, mitochondria, macrophages, animals, mice, knockout, humans, mice, mammary neoplasms, experimental, obesity, reactive oxygen species, dietary fats, fish oils, female, fatty acid-binding proteins, primary cell culture, diet, high-fat, carcinogenesis
13 autores
- Lianliang Liu🇨🇳🇺🇸Ningbo University; University of Louisville
- Rong Jin🇺🇸🇨🇳University of Louisville; Peking University
- Jiaqing Hao🇺🇸University of Louisville
- Jun Zeng🇺🇸🇨🇳University of Louisville; Guangzhou Medical University
- Di Yin🇺🇸🇨🇳University of Louisville; Guangzhou Medical University
- Yanmei Yi🇺🇸🇨🇳University of Louisville; Guangdong Medical College
- Mingming Zhu🇺🇸University of Louisville; University of Louisville Hospital; University of Louisville Physicians
- Anita Mandal🇺🇸University of Louisville
- Yuan Hua🇺🇸University of Louisville
- Chin K. Ng🇺🇸University of Louisville; University of Louisville Hospital; University of Louisville Physicians
- Nejat K. Egilmez🇺🇸University of Louisville
- Edward R. Sauter🇺🇸Center for Cancer Research
- Bing Li🇺🇸University of Louisville
Resumen
El texto original del estudio, en el idioma en que se publicó.
Obesity is associated with increased risk of many types of cancer and can be induced by various high-fat diets (HFD) from different fat sources. It remains unknown whether fatty acid composition in different HFD influences obesity-associated tumor development. Here we report that consumption of either a cocoa butter or fish oil HFD induced similar obesity in mouse models. While obesity induced by the cocoa butter HFD was associated with accelerated mammary tumor growth, consumption of the fish oil HFD uncoupled obesity from increased mammary tumor growth and exhibited a decrease in protumor macrophages. Compared with fatty acid (FA) components in both HFDs, n-3 FA rich in the fish oil HFD induced significant production of reactive oxygen species (ROS) and macrophage death. Moreover, A-FABP expression in the protumor macrophages facilitated intracellular transportation of n-3 FA and oxidation of mitochondrial FA. A-FABP deficiency diminished n-3 FA-mediated ROS production and macrophage death in vitro and in vivo. Together, our results demonstrate a novel mechanism by which n-3 FA induce ROS-mediated protumor macrophage death in an A-FABP-dependent manner. SIGNIFICANCE: This study provides mechanistic insight into dietary supplementation with fish oil for breast cancer prevention and advances a new concept that not all HFDs leading to obesity are tumorigenic. GRAPHICAL ABSTRACT: http://cancerres.aacrjournals.org/content/canres/80/12/2564/F1.large.jpg.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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