Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
Revez JA, Lin T, Qiao Z, Xue A, Holtz Y, Zhu Z, Zeng J, Wang H, Sidorenko J, Kemper KE, Vinkhuyzen AAE, Frater J, Eyles D, Burne THJ, Mitchell B, Martin NG, Zhu G, Visscher PM, Yang J, Wray NR, McGrath JJ
Nature communications · 344 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Queensland Health
- Universidad u hospital
- QIMR Berghofer Medical Research Institute
- Gobierno
- National Research Foundation
- Gobierno
- Danmarks Grundforskningsfond
- Universidad u hospital
- Queensland University of Technology
- Gobierno
- National Institutes of Health
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- Medical Research Council
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- Australian Research Council
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- National Health and Medical Research Council
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- National Heart, Lung, and Blood Institute
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- National Institute of Mental Health
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- National Institute on Drug Abuse
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- National Human Genome Research Institute
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- NIH Office of the Director
- Gobierno
- National Cancer Institute
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- National Institute of Neurological Disorders and Stroke
- Gobierno
- Common Fund
- Subvenciones
- Queensland University of Technology (1113400); Medical Research Council (1113400); National Health and Medical Research Council (1124721); National Health and Medical Research Council (1007677); National Health and Medical Research Council (1113400); National Health and Medical Research Council (1078901); National Institutes of Health (12505); Medical Research Council (1078037); National Health and Medical Research Council (1124724); Queensland University of Technology (1078901); Australian Research Council (1113400); National Health and Medical Research Council (1056929); Medical Research Council (1078901); Australian Research Council (FT180100186); National Health and Medical Research Council (1078037); National Health and Medical Research Council (1099709); National Health and Medical Research Council (1141699)
Según 17 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-04-02 · Nat Commun · vol. 11 · número 1 · pág. 1647
- Editorial
- Nature Portfolio
- Citado
- 461 citas · más que el 100% de estudios similares · 28.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 91 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Genetic Associations and Epidemiology · Digestive system and related health
- Palabras clave
- Genome-wide association study, Biology, Genome, Computational biology, Genetics, Association (psychology), Gene, Single-nucleotide polymorphism, Genotype, Psychology
- MeSH
- humans, vitamin d deficiency, vitamin d, polymorphism, single nucleotide, adult, aged, middle aged, female, male, genome-wide association study, mendelian randomization analysis, united kingdom, white people
21 autores
- Joana Revez🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Tian Lin🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Zhen Guo Qiao🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Angli Xue🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Yan Holtz🇦🇺The University of Queensland
- Zhihong Zhu🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Jian Zeng🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Huanwei Wang🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Julia Sidorenko🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Kathryn E. Kemper🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Anna A. E. Vinkhuyzen🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Julanne Frater🇦🇺The University of Queensland
- Darryl Walter Eyles🇦🇺The University of Queensland; Park Centre for Mental Health; Queensland Centre for Mental Health Research
- Thomas H.J. Burne🇦🇺The University of Queensland; Park Centre for Mental Health; Queensland Centre for Mental Health Research
- Brittany L. Mitchell🇦🇺Queensland University of Technology; QIMR Berghofer Medical Research Institute
- Nicholas G. Martin🇦🇺QIMR Berghofer Medical Research Institute
- Gu Zhu🇦🇺QIMR Berghofer Medical Research Institute
- Peter M. Visscher🇦🇺The University of Queensland; Institute for Molecular Bioscience
- Jian Yang🇦🇺🇨🇳The University of Queensland; Wenzhou Medical University; Institute for Molecular Bioscience
- Naomi R. Wray🇦🇺 · autor de correspondenciaThe University of Queensland
- John Joseph McGrath🇦🇺🇩🇰 · autor de correspondenciaThe University of Queensland; Aarhus University; Park Centre for Mental Health; Mater Research; Queensland Centre for Mental Health Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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