Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study
Chow LS, Manoogian ENC, Alvear A, Fleischer JG, Thor H, Dietsche K, Wang Q, Hodges JS, Esch N, Malaeb S, Harindhanavudhi T, Nair KS, Panda S, Mashek DG
Obesity (Silver Spring, Md.) · 312 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Sin clasificar
- Healthy Foods Healthy Lives
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences ((UL1-TR002494)); National Cancer Institute (P30 CA-014195)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2020-04-09 · Obesity (Silver Spring) · vol. 28 · número 5 · págs. 860–869
- Editorial
- Wiley
- Citado
- 363 citas · más que el 100% de estudios similares · 22.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Enhanced Recovery After Surgery
- Palabras clave
- Overweight, Medicine, Weight loss, Lean body mass, Obesity, Randomized controlled trial, Body mass index, Anthropometry, Internal medicine, Animal science, Endocrinology, Body weight, Physical therapy, Biology
- MeSH
- humans, obesity, feasibility studies, body composition, adolescent, adult, aged, middle aged, female, male, overweight, young adult
14 autores
- Lisa Senye Chow🇺🇸 · autor de correspondenciaUniversity of Minnesota
- Emily N. C. Manoogian🇺🇸Salk Institute for Biological Studies
- ALISON C. ALVEAR🇺🇸University of Minnesota
- Jason G. Fleischer🇺🇸Salk Institute for Biological Studies
- Honoree Thor🇺🇸University of Minnesota
- KATRINA B. DIETSCHE🇺🇸University of Minnesota
- Qi Wang🇺🇸University of Minnesota
- James S. Hodges🇺🇸University of Minnesota
- Nicholas Esch🇺🇸University of Minnesota
- Samar Malaeb🇺🇸University of Minnesota
- Tasma Harindhanavudhi🇺🇸University of Minnesota
- K. Sreekumaran Nair🇺🇸Mayo Clinic
- Satchidananda Panda🇺🇸Salk Institute for Biological Studies
- Douglas G. Mashek🇺🇸University of Minnesota
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time-restricted eating (TRE) with an unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.
Methods
Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m2 ) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n = 11: 8-hour window, unrestricted eating within window) versus non-TRE (n = 9: unrestricted eating) for 12 weeks. Weight, body composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous glucose monitoring, and 2-week physical activity (actigraphy assessed) were measured during the pre- and end-intervention periods.
Results
The TRE group significantly reduced the eating window (end-intervention window: 9.9 [2.0] hours) compared with the non-TRE group (end-intervention window: 15.1 [1.1] hours) (P < 0.01). Compared with non-TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all P ≤ 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (-21.9% [30.1%]) and reduced weight (-3.7% [1.8%]), fat mass (-4% [2.9%]), lean mass (-3.0% [2.7%]), and visceral fat (-11.1% [13.4%]) (all P ≤ 0.05). Physical activity and metabolic measures remained unchanged.
Conclusions
In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.
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