Enhanced bone mineralization using hydroxyapatite-based ceramic bone substitute incorporating Withania somnifera extracts
Qayoom I, Teotia AK, Meena M, Singh P, Mishra A, Singh S, Kumar A
Biomedical materials (Bristol, England) · 17 citas
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Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Department of Biotechnology, Ministry of Science and Technology, India
- Gobierno
- Department of Science and Technology, Ministry of Science and Technology, India
- Gobierno
- Department of Science and Technology, Ministry of Science and Technology
- Gobierno
- Uchchatar Avishkar Yojana,
- Gobierno
- Department of Biotechnology , Ministry of Science and Technology
- Subvenciones
- Department of Biotechnology, Ministry of Science and Technology, India (BT/IN/SWEDEN/08/AK/2017-18); Department of Science and Technology, Ministry of Science and Technology, India ((#DST/NM/NT-2018/48))
Según 5 financiadores declarados.
Publicación
- Publicado
- 2020-04-09 · Biomed Mater · vol. 15 · número 5 · pág. 055015
- Editorial
- IOP Publishing
- Citado
- 23 citas · más que el 72% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Phytochemicals and Medicinal Plants
- Palabras clave
- Withania somnifera, Biocompatibility, Chitosan, Materials science, Withaferin A, Calcium, Biomedical engineering, Mineralization (soil science), In vitro, Dentistry, Chemistry, Biochemistry, Medicine, Organic chemistry, Metallurgy
- MeSH
- bone and bones, cell line, tumor, 3t3 cells, osteoblasts, animals, humans, mice, withania, calcium phosphates, hydroxyapatites, durapatite, methanol, chitosan, bone cements, bone substitutes, ceramics, powders, microscopy, electron, scanning, spectroscopy, fourier transform infrared, bone regeneration, cell adhesion, cell differentiation, cell proliferation, calcification, physiologic, particle size, stress, mechanical, in vitro techniques
7 autores
- Irfan Qayoom🇮🇳Indian Institute of Technology Kanpur
- Arun Kumar Teotia🇮🇳Indian Institute of Technology Kanpur
- Megha Meena🇮🇳Indian Institute of Technology Kanpur
- Prerna Singh🇮🇳Indian Institute of Technology Kanpur
- Ankita Mishra🇮🇳Indian Institute of Technology Kanpur
- Sneha Singh🇮🇳Birla Institute of Technology, Mesra
- Ashok Kumar🇮🇳 · autor de correspondenciaIndian Institute of Technology Kanpur
Resumen
El texto original del estudio, en el idioma en que se publicó.
Withania somnifera (ashwagandha) is used in Indian traditional medicine for its various health benefits. Withaferin-A, a steroidal lactone present in this herb, has shown proteosomal inhibition-based enhancement of bone mineralization. In the present work, chitosan microparticles blended with total methanolic root extract of W. somnifera were incorporated as a porogen in calcium phosphate-based hydroxyapatite bone filler. The controlled release of bioactive molecules enabled enhanced proliferation and differentiation of pre-osteoblasts. Microparticle percentages were optimized to have a minimum effect on the setting time, mechanical strength and degradability of hydroxyapatite bone filler. In vitro cell adhesion, proliferation and differentiation were evaluated to determine the biocompatibility of the composites. On the basis of the desirable results obtained, we provide a preliminary rationale for the use of methanolic extract-blended chitosan microparticle-impregnated calcium phosphate filler for enhanced bone regeneration.
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