Magnesium supplementation and preeclampsia in low-income pregnant women - a randomized double-blind clinical trial
de Araújo CAL, de Sousa Oliveira L, de Gusmão IMB, Guimarães A, Ribeiro M, Alves JGB
BMC pregnancy and childbirth · 19 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Bill and Melinda Gates Foundation
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Organización sin fines de lucro
- Bill & Melinda Gates Foundation
- Organización sin fines de lucro
- Bill & Melinda Gates Foundation
- Gobierno
- CNPq
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (4399862016-8); Bill and Melinda Gates Foundation (OPP1107597); Bill and Melinda Gates Foundation (4399862016-8)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-04-09 · BMC Pregnancy Childbirth · vol. 20 · número 1 · pág. 208
- Editorial
- BioMed Central
- Citado
- 28 citas · más que el 89% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Pregnancy and preeclampsia studies · Magnesium in Health and Disease · Preterm Birth and Chorioamnionitis
- Palabras clave
- Medicine, Preeclampsia, Eclampsia, Obstetrics, Pregnancy, Placebo, Randomized controlled trial, Population, Incidence (geometry), Randomization, Gynecology, Internal medicine
- MeSH
- humans, pre-eclampsia, magnesium deficiency, magnesium sulfate, double-blind method, gestational age, pregnancy, poverty, dietary supplements, adult, brazil, female, young adult
6 autores
- Carla Adriane Leal de Araújo🇧🇷Instituto de Medicina Integral Professor Fernando Figueira
- Larissa de Sousa Oliveira🇧🇷Faculdade Frassinetti do Recife; Faculdade Pernambucana de Saúde
- Isabela Melo Buarque de Gusmão🇧🇷Faculdade Frassinetti do Recife; Faculdade Pernambucana de Saúde
- Angélica Guimarães🇧🇷Fundacao Joaquim Nabuco
- Moranna Ribeiro🇧🇷Instituto de Medicina Integral Professor Fernando Figueira
- João Guilherme Bezerra Alves🇧🇷 · autor de correspondenciaInstituto de Medicina Integral Professor Fernando Figueira
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Preeclampsia is the major cause of maternal morbidity and mortality in developing countries. Magnesium sulfate is considered first-line therapy against eclampsia and magnesium deficiency in pregnancy has been associated with unfavourable perinatal outcomes. However there are doubts if magnesium supplementation during pregnancy can previne preeclampsia especially in population with high nutritional risk. This trial aims to verify the effect of oral magnesium supplmentation on preeclampsia incidence in low income pregnant women.
Methods
This randomized, double-blind, placebo-controlled trial investigated the effect of oral magnesium citrate supplementation for preeclampsia in low-income Brazilian pregnant women, i.e. annual per capita income of US$ 1025 or less. Participants were admitted to the study with gestational age between 12 and 20 weeks. Magnesium serum level was measured pre-randomization and participants with hypermagnesemia were excluded. After randomizationg participants received magnesium citrate capsule (300 mg magnesium citrate) or a daily placebo capsule, until delivery. Intent-to-treat analysis was performed.
Results
A total of 416 pregnant women were screened and 318 enrolled according to the inclusion criteria; 159 for each arm. Twenty-eight pregnant women were lost to follow-up. 55/290 (18.9%) of pregnant women developed preeclampsia; 26/143 (18.1%) in magnesium group and 29/147 (19.7%) in the control group; OR 0.90 (CI 95% 0.48-1.69), p = 0.747. No cases of eclampsia were registered.
Conclusion
Oral magnesium supplementation did not reduce preeclampsia incidence in low-income and low-risk pregnant women.
Trial registration
Registered at ClinicalTrials.gov (Identifier NCT02032186), December 19, 2013.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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