Dietary nitrate does not acutely enhance skeletal muscle blood flow and vasodilation in the lower limbs of older adults during single-limb exercise
Hughes WE, Kruse NT, Ueda K, Feider AJ, Hanada S, Bock JM, Casey DP
European journal of applied physiology · 10 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Diabetes Association
- Subvenciones
- American Diabetes Association (1-16-1CTA-015)
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-04-17 · Eur J Appl Physiol · vol. 120 · número 6 · págs. 1357–1369
- Editorial
- Springer Science+Business Media
- Citado
- 10 citas · más que el 81% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 62 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Nitric Oxide and Endothelin Effects
- Palabras clave
- dietary nitrate, nitric oxide bioavailability, skeletal muscle blood flow, vasodilation, older adults, knee extension exercise, hyperemia, vascular conductance, lower extremity, submaximal exercise, nitrite
- MeSH
- lower extremity, muscle, skeletal, femoral artery, humans, nitrates, composite resins, glass ionomer cements, ultrasonography, doppler, exercise, double-blind method, blood pressure, heart rate, regional blood flow, vasodilation, muscle contraction, aged, female, male, hemodynamics
7 autores
- William Edward Hughes🇺🇸University of Iowa
- Nicholas T. Kruse🇺🇸University of Iowa
- Kenichi Ueda🇺🇸University of Iowa
- Andrew J. Feider🇺🇸University of Iowa
- Satoshi Hanada🇺🇸University of Iowa
- Joshua M. Bock🇺🇸University of Iowa
- Darren P. Casey🇺🇸 · autor de correspondenciaUniversity of Iowa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Blood flow (BF) and vasodilator responses to knee-extension exercise are attenuated in older adults across an exercise transient (onset, kinetics, and steady-state), and reduced nitric oxide bioavailability (NO) has been hypothesized to be a primary mechanism contributing to this attenuation. We tested the hypothesis acute dietary nitrate (NO3-) supplementation (~ 4.03 mmol NO3- and 0.29 mmol NO2-) would improve leg vasodilator responses across an exercise transient during lower limb exercise in older adults.
Methods
Older (n = 10) untrained adults performed single and rhythmic knee-extension contractions at 20% and 40% work-rate maximum (WRmax) prior to and 2-h after consuming a NO3- or placebo beverage in a double-blind, randomized fashion. Femoral artery BF was measured by Doppler ultrasound. Vascular conductance was calculated using BF and mean arterial pressure.
Results
Acute ingestion of dietary NO3- enhanced plasma [NO3-] and [NO2-] (P 3- or placebo enhanced vasodilator responses at the onset of exercise or during steady state at 20% and 40% WRmax (P > 0.05). Leg vasodilator kinetics during rhythmic exercise remained unchanged following NO3- and placebo ingestion (P > 0.05).
Conclusions
The key findings of this study are that despite increasing plasma [NO3-] and [NO2-], acute dietary NO3- intake had no effect on (1) rapid hyperaemic or vasodilator responses at the onset of exercise; (2) hyperaemic and vasodilator responses during steady-state submaximal exercise; or (3) kinetics of vasodilation preceding steady-state responses. Collectively, these findings suggest that low dose dietary NO3- supplementation does not improve hyperaemic and vasodilator responses across an exercise transient in older adults.
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