Analysis of 25-hydroxy cholecalciferol, immunoglobulin E, and vitamin D receptor single nucleotide polymorphisms (Apa1, Taq1, and Bsm1), among sample of Egyptian children with bronchial asthma: A case-control study
Ahmed AE, Hassan MH, Toghan R, Rashwan NI
Pediatric pulmonology · 10 citas
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Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-04-20 · Pediatr Pulmonol · vol. 55 · número 6 · págs. 1349–1358
- Editorial
- Wiley
- Citado
- 17 citas · más que el 78% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Asthma and respiratory diseases · Health, Environment, Cognitive Aging
- Palabras clave
- Medicine, Confidence interval, Asthma, Odds ratio, Calcitriol receptor, Vitamin D and neurology, Immunoglobulin E, Single-nucleotide polymorphism, Internal medicine, Vital capacity, Gastroenterology, Body mass index, Immunology, Genotype, Antibody, Lung, Biology, Genetics
- MeSH
- humans, asthma, vitamin d deficiency, genetic predisposition to disease, calcifediol, immunoglobulin e, receptors, calcitriol, odds ratio, case-control studies, genotype, polymorphism, single nucleotide, alleles, adolescent, child, egypt, female, male
4 autores
- Ahmed El‐Abd Ahmed🇪🇬South Valley University
- Mohammed H. Hassan🇪🇬 · autor de correspondenciaSouth Valley University
- Rana Toghan🇪🇬South Valley University
- Nagwan Ibrahim Rashwan🇪🇬South Valley University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The current study aimed to assess the serum levels of vitamin D and immunoglobulin E (IgE) among asthmatic Egyptian children and to find out the possible associations of vitamin D receptor (VDR) polymorphisms with bronchial asthma development.
Methods
The study included 100 Egyptian children, 50 asthmatic children who were comparable with 50 age, sex, and body mass index-matched, unrelated healthy controls (HCs) clinical assessments of asthmatic children were done using global initiative of asthma. Pulmonary function tests (forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], FEV1/FVC ratio) were performed. Enzyme-linked immunosorbent assays of serum vitamin D3 and total IgE were done. VDR-single nucleotide polymorphisms (SNPs) (ApaI, TaqI, and BsmI) detection has performed using polymerase chain reaction through restriction fragment length polymorphism technique. Data analysis was performed using SPSS version 20.0. The studied SNPs were followed the Hardy Weinberg equation.
Results
The mean serum level of 25(OH) D3 was significantly lower among asthmatic children (13.46 ng/mL ± 10.50 SD) in comparison to HCs (37.53 ng/mL ± 13. 0.40 SD), P .05). TT + Tt and Bb + bb genotypes were significantly higher among cases versus the controls, P < .05 for all.
Conclusions
TaqI and BsmI were associated with risk of bronchial asthma development among Egyptian children. High IgE and Low vitamin D status were frequently occurring among asthmatic children.
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