Music Intervention Reduces Persistent Fibromyalgia Pain and Alters Functional Connectivity Between the Insula and Default Mode Network
Usui C, Kirino E, Tanaka S, Inami R, Nishioka K, Hatta K, Nakajima T, Nishioka K, Inoue R
Pain medicine (Malden, Mass.) · 20 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Japan Society for the Promotion of Science
- Universidad u hospital
- Research Support Foundation 2018 of the Juntendo Institute of Mental Health
- Subvenciones
- Japan Society for the Promotion of Science (19K08026); Japan Society for the Promotion of Science (15K00380)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-02-18 · Pain Med · vol. 21 · número 8 · págs. 1546–1552
- Editorial
- Oxford University Press
- Citado
- 37 citas · más que el 90% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fibromyalgia and Chronic Fatigue Syndrome Research · Musculoskeletal pain and rehabilitation · Pain Mechanisms and Treatments
- Palabras clave
- Default mode network, Insula, Functional magnetic resonance imaging, Fibromyalgia, Medicine, Physical therapy, Precuneus, Music therapy, Functional connectivity, Audiology, Physical medicine and rehabilitation, Psychology, Neuroscience
- MeSH
- brain, cerebral cortex, neural pathways, humans, fibromyalgia, magnetic resonance imaging, music therapy, brain mapping, pilot projects, music, female, default mode network
9 autores
- Chie Usui🇯🇵 · autor de correspondenciaJuntendo University; Juntendo University Nerima Hospital
- Eiji Kirino🇯🇵Juntendo University; Juntendo University Shizuoka Hospital
- Shoji Tanaka🇯🇵Sophia University
- Rie Inami🇯🇵Juntendo University
- Kenya Nishioka🇯🇵National Graduate Institute for Policy Studies; Juntendo University
- Kotaro Hatta🇯🇵Juntendo University; Juntendo University Nerima Hospital
- Toshihiro Nakajima🇯🇵Tokyo Medical University
- Kusuki Nishioka🇯🇵National Graduate Institute for Policy Studies; Juntendo University
- Reiichi Inoue🇯🇵Juntendo University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aims of the present study were to examine the effects of short-term music interventions among patients with fibromyalgia (FM) and to clarify the alterations in functional connectivity and persistent pain.
Design
Pilot study.
Setting
All participants were evaluated at Juntendo University from November 2017 to January 2019.
Subjects
We enrolled female patients who had been clinically diagnosed with FM (N = 23).
Methods
All participants listened to Mozart's Duo for Violin and Viola No. 1, K. 423, in a quiet room for 17 minutes. We compared the degree of pain using resting-state functional magnetic resonance imaging and the numeric rating scale before and after listening to music.
Results
Pain scores were significantly reduced after listening to music. Further, we observed there was a significant difference in connectivity between the right insular cortex (IC) and posterior cingulate cortex (PCC)/precuneus (PCu) before and after listening to music. We also found that the difference between the right IC-PCu connectivity and the difference in pain scores were significantly correlated.
Conclusions
We found that a short period of music intervention reduced chronic pain and altered functional IC-default mode network connectivity. Furthermore, music potentially normalized the neural network via IC-default mode network connectivity, yielding temporary pain relief in patients with FM. Further longitudinal studies with larger sample sizes are required to confirm these results.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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