Photobiomodulation Therapy is Able to Modulate PGE2 Levels in Patients With Chronic Non-Specific Low Back Pain: A Randomized Placebo-Controlled Trial
Tomazoni SS, Costa LOP, Joensen J, Stausholm MB, Naterstad IF, Ernberg M, Leal-Junior ECP, Bjordal JM
Lasers in surgery and medicine · 20 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2017/18863‐6)
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-04-24 · Lasers Surg Med · vol. 53 · número 2 · págs. 236–244
- Editorial
- Wiley
- Citado
- 26 citas · más que el 76% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Pain Management and Treatment · Musculoskeletal pain and rehabilitation
- Palabras clave
- low-level laser therapy, chronic non-specific low back pain, prostaglandin E2, inflammatory mediators, TNF-α, interleukin-6, pain intensity, analgesic mechanism
- MeSH
- humans, low back pain, dinoprostone, tumor necrosis factor-alpha, interleukin-6, low-level light therapy
8 autores
- Shaiane Silva Tomazoni🇧🇷🇳🇴 · autor de correspondenciaUniversidade Cidade de São Paulo; University of Bergen
- Leonardo Oliveira Pena Costa🇧🇷Universidade Cidade de São Paulo
- Jón Joensen🇳🇴University of Bergen
- Martin Bjørn Stausholm🇳🇴University of Bergen
- Ingvill Fjell Naterstad🇳🇴University of Bergen
- Malin M Ernberg🇸🇪Karolinska Institutet
- Ernesto César Pinto Leal‐Junior🇧🇷🇳🇴Universidade Nove de Julho; University of Bergen
- Jan Magnus Bjordal🇳🇴University of Bergen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Non-specific low back pain (LBP) is responsible for triggering increased biomarkers levels. In this way, photobiomodulation therapy (PBMT) may be an interesting alternative to treat these patients. One of the possible biological mechanisms of PBMT involved to decrease pain intensity in patients with musculoskeletal disorders is modulation of the inflammatory mediators' levels. The aim of this study was to evaluate the effects of PBMT compared with placebo on inflammatory mediators' levels and pain intensity in patients with chronic non-specific LBP.
Study design/materials and methods
A prospectively registered, randomized triple-blinded (volunteers, therapists, and assessors), placebo-controlled trial was performed. Eighteen patients with chronic non-specific LBP were recruited and treated with a single session of active PBMT or placebo PBMT. The primary outcome of the study was serum prostaglandin E2 levels and the secondary outcomes were tumor necrosis factor-α, interleukin-6 levels, and pain intensity. All outcomes were measured before and after 15 minutes of treatment session.
Results
PBMT was able to decrease prostaglandin E2 levels at post-treatment compared with placebo, with a mean difference of -1470 pg/ml, 95% confidence interval -2906 to -33.67 in patients with LBP. There was no difference between groups in the other measured outcomes. Patients did not report any adverse events.
Conclusion
Our results suggest that PBMT was able to modulate prostaglandin E2 levels, indicating that this may be one of the mechanisms involved in the analgesic effects of PBMT in patients with LBP. Trial registration number (ClinicalTrials.gov): NCT03859505. Lasers Surg. Med. © 2020 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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