Financiado en parte por U.S. Highbush Blueberry Council, US Highbush Blueberry Council
Effect of Blueberry Consumption on Cardiometabolic Health Parameters in Men with Type 2 Diabetes: An 8-Week, Double-Blind, Randomized, Placebo-Controlled Trial
Stote KS, Wilson MM, Hallenbeck D, Thomas K, Rourke JM, Sweeney MI, Gottschall-Pass KT, Gosmanov AR
Current developments in nutrition · 55 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Grupo de la industria
- US Highbush Blueberry Council
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-03-06 · Curr Dev Nutr · vol. 4 · número 4 · pág. nzaa030
- Editorial
- Elsevier BV
- Citado
- 78 citas · más que el 96% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Phytoestrogen effects and research · Food composition and properties
- Palabras clave
- Type 2 diabetes, Fructosamine, Placebo, Medicine, Evening, Diabetes mellitus, Aspartate transaminase, Alanine transaminase, Internal medicine, Morning, Randomized controlled trial, Gastroenterology, Animal science, Endocrinology, Chemistry, Biology, Biochemistry, Alkaline phosphatase
8 autores
- Kim S. Stote🇺🇸 · autor de correspondenciaAlbany Stratton VA Medical Center Albany
- Margaret Mary Wilson🇺🇸Albany Stratton VA Medical Center Albany
- Deborah Hallenbeck🇺🇸Albany Stratton VA Medical Center Albany
- Krista Thomas🇺🇸Sage Colleges
- Joanne M Rourke🇺🇸Albany Stratton VA Medical Center Albany
- Marva I. Sweeney🇨🇦University of Prince Edward Island
- Katherine T. Gottschall‐Pass🇨🇦University of Prince Edward Island
- Aidar R. Gosmanov🇺🇸Albany Stratton VA Medical Center Albany
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Blueberries are dietary sources of polyphenols, specifically anthocyanins. Anthocyanins have been identified as having a strong association with type 2 diabetes risk reduction; however, to date few human clinical trials have evaluated the potential beneficial health effects of blueberries in populations with type 2 diabetes.
Objectives
We investigated the effects of blueberry consumption for 8 wk on cardiometabolic parameters in men with type 2 diabetes.
Methods
In a double-blind, parallel-arm, randomized controlled trial, 52 men who are US veterans [mean baseline characteristics: age, 67 y (range: 51-75 y); weight, 102 kg (range: 80-130 kg); BMI (in kg/m2), 34 (range: 26-45)] were randomly assigned to 1 of 2 intervention groups. The interventions were either 22 g freeze-dried blueberries or 22 g placebo. The study participants were asked to consume 11 g freeze-dried blueberries or placebo with each of their morning and evening meals along with their typical diet.
Results
Mean ± SE hemoglobin A1c (7.1% ± 0.1% compared with 7.5% ± 0.2%; P = 0.03), fructosamine (275.5 ± 4.1 compared with 292.4 ± 7.9 µmol/L; P = 0.04), triglycerides (179.6 ± 10.1 compared with 199.6 ± 19.9 mg/dL; P = 0.03), aspartate transaminase (23.2 ± 1.4 compared with 30.5 ± 2.7 units/L; P = 0.02), and alanine transaminase (35.6 ± 1.5 compared with 48.3 ± 2.9 units/L; P = 0.0003) were significantly lower for those consuming blueberries for 8 wk than for those consuming the placebo. Fasting plasma glucose concentrations; serum insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, and C-reactive protein concentrations; blood pressure; and body weight were not significantly different after 8 wk consumption of blueberries compared with the placebo.
Conclusions
Consumption of 22 g freeze-dried blueberries for 8 wk may beneficially affect cardiometabolic health parameters in men with type 2 diabetes.This trial was registered at clinicaltrials.gov as NCT02972996.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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