The Effects of Magnesium Supplementation on Blood Pressure and Obesity Measure Among Type 2 Diabetes Patient: a Systematic Review and Meta-analysis of Randomized Controlled Trials
Asbaghi O, Hosseini R, Boozari B, Ghaedi E, Kashkooli S, Moradi S
Biological trace element research · 30 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-05-08 · Biol Trace Elem Res · vol. 199 · número 2 · págs. 413–424
- Editorial
- Springer Science+Business Media
- Citado
- 54 citas · más que el 82% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Blood Pressure and Hypertension Studies · Magnesium Alloys: Properties and Applications
- Palabras clave
- magnesium supplementation, type 2 diabetes, blood pressure, obesity, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure
- MeSH
- humans, diabetes mellitus, type 2, obesity, magnesium, blood pressure, dietary supplements, randomized controlled trials as topic
6 autores
- Omid Asbaghi🇮🇷Lorestan University of Medical Sciences
- Reza Hosseini🇮🇷Isfahan University of Medical Sciences
- Behnoosh Boozari🇮🇷Isfahan University of Medical Sciences
- Ehsan Ghaedi🇮🇷Tehran University of Medical Sciences
- Sara Kashkooli🇮🇷Lorestan University of Medical Sciences
- Sajjad Moradi🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
In this study, we aimed to systematically review the literature to evaluate the effects of magnesium (Mg) supplementation on blood pressure (BP) and obesity measure among patients with type 2 diabetes mellitus (T2DM). Major electronic databases of Web of Science, the Cochrane library, PubMed, and Scopus were searched completely from the inception until 15 October 2019 to identify randomized clinical trials (RCTs) pertaining to the topic of interest. All outcomes were pooled using a random-effects model and expressed as weighted mean differences (WMD) with 95% confidential intervals (CI). Heterogeneity, sensitivity analysis, and publication bias were also assessed using standard methods. The pooled analysis of five RCTs showed that Mg supplementation did not affect body weight (WMD: - 0.01 kg, 95% CI: - 0.36 to 0.33), BMI (WMD: - 0.07, 95% CI: - 0.18 to 0.04), and waist circumference (WMD: 0.12, 95% CI: - 1.24 to 1.48) in T2DM patients compared to the control groups of the patients who received placebo. However, pooling seven RCTs together showed significant reduction of systolic blood pressure (WMD: - 5.78 mmHg, 95% CI: - 11.37 to - 0.19) and diastolic blood pressure (WMD: - 2.50 mmHg, 95% CI: - 4.58 to - 0.41) in T2DM patients. Furthermore, subgroup analysis by dose of intervention, intervention duration, and type of intervention suggested that Mg supplementation for > 12 weeks, in doses higher than 300 mg/day or inorganic forms, could significantly decrease both systolic and diastolic BP in T2DM patients. Based on the findings, Mg supplementation has beneficial effects on BP in type 2 diabetes patients independent of body weight status. However, further investigations are needed to provide more reliable evidences.
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