Walnut (Juglans regia L.) Septum: Assessment of Bioactive Molecules and In Vitro Biological Effects
Rusu ME, Fizesan I, Pop A, Mocan A, Gheldiu AM, Babota M, Vodnar DC, Jurj A, Berindan-Neagoe I, Vlase L, Vlase L, Popa DS
Molecules (Basel, Switzerland) · 38 citas
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- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-05-07 · Molecules · vol. 25 · número 9 · pág. 2187
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 69 citas · más que el 96% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Phytochemicals and Antioxidant Activities
- Palabras clave
- Juglans, Chemistry, Phytochemical, Cytotoxicity, Antimicrobial, In vitro, Food science, Biochemistry
- MeSH
- cell line, tumor, humans, pseudomonas aeruginosa, salmonella enteritidis, staphylococcus aureus, juglans, nuts, lipase, tocopherols, cholinesterase inhibitors, anti-inflammatory agents, interleukin-8, plant extracts, interleukin-6, antimutagenic agents, antioxidants, anti-infective agents, chromatography, liquid, apoptosis, interleukin-1beta, tandem mass spectrometry, glycoside hydrolase inhibitors
11 autores
- Marius Emil Rusu🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Ionel Fizeșan🇷🇴 · autor de correspondenciaIuliu Hațieganu University of Medicine and Pharmacy
- Anca Pop🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Andrei Mocan🇷🇴 · autor de correspondenciaIuliu Hațieganu University of Medicine and Pharmacy
- Ana-Maria Gheldiu🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Mihai Babotă🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Dan Cristian Vodnar🇷🇴University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
- Ancuta Maria Jurj🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Ioana Berindan-Neagoe🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy; Institute of Oncology Prof. Dr. Ion Chiricuta
- Laurian Vlase🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Daniela‐Saveta Popa🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
Resumen
El texto original del estudio, en el idioma en que se publicó.
Walnut (Juglans regia L.) septum represents an interesting bioactive compound source by-product. In our study, a rich phenolic walnut septum extract, previously selected, was further examined. The tocopherol content determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) revealed higher amounts of α-tocopherol compared to γ- and δ-tocopherols. Moreover, several biological activities were investigated. The in vitro inhibiting assessment against acetylcholinesterase, α-glucosidase, or lipase attested a real management potential in diabetes or obesity. The extract demonstrated very strong antimicrobial potential against Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella enteritidis. It also revealed moderate (36.08%) and strong (43.27%) antimutagenic inhibitory effects against TA 98 and TA 100 strains. The cytotoxicity of the extract was assessed on cancerous (A549, T47D-KBluc, MCF-7) and normal (human gingival fibroblasts (HGF)) cell lines. Flow cytometry measurements confirmed the cytotoxicity of the extract in the cancerous cell lines. Additionally, the extract demonstrated antioxidant activity on all four cell types, as well as anti-inflammatory activity by lowering the inflammatory cytokines (interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-1 β (IL-1β)) evaluated in HGF cells. To the best of our knowledge, most of the cellular model analyses were performed for the first time in this matrix. The results prove that walnut septum may be a potential phytochemical source for pharmaceutical and food industry.
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