Whole-Grain Processing and Glycemic Control in Type 2 Diabetes: A Randomized Crossover Trial
Åberg S, Mann J, Neumann S, Ross AB, Reynolds AN
Diabetes care · 68 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Laurenson Award of the Otago Medical Research Foundation
- Universidad u hospital
- The Riddet Centre of Research Excellence
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-05-18 · Diabetes Care · vol. 43 · número 8 · págs. 1717–1723
- Editorial
- American Diabetes Association
- Citado
- 100 citas · más que el 97% de estudios similares · 5.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Celiac Disease Research and Management · Consumer Attitudes and Food Labeling
- Palabras clave
- Medicine, Crossover study, Glycemic, Postprandial, Randomized controlled trial, Diabetes mellitus, Type 2 diabetes, Internal medicine, Psychological intervention, Endocrinology, Placebo
- MeSH
- humans, triticum, diabetes mellitus, type 2, blood glucose, blood glucose self-monitoring, cross-over studies, energy intake, postprandial period, food handling, aged, middle aged, new zealand, female, male, meals, breakfast, whole grains, glycemic control
5 autores
- Sebastian Åberg🇸🇪🇳🇿Karolinska Institutet; University of Otago
- Jim I. Mann🇳🇿Riddet Institute; University of Otago
- Silke Neumann🇳🇿University of Otago
- Alastair B. Ross🇳🇿Lincoln University; AgResearch
- Andrew Nathan Reynolds🇳🇿 · autor de correspondenciaRiddet Institute; University of Otago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To consider the effects of whole-grain processing, specifically milling, on glycemic control in free-living adults with type 2 diabetes.
Research design and methods
Participants of this crossover trial were randomized to two interventions of 2 weeks, separated by washout. They were advised to replace the grain foods they normally consumed with intervention foods. Intervention foods were nutrient-matched whole-grain products of wheat, oats, and brown rice that differed in their degree of processing. No other lifestyle advice was given. Continuous glucose monitoring systems were worn. Other cardiometabolic risk factors and alkylresorcinols (a biomarker of whole-grain intake) were measured pre- and postintervention.
Results
Thirty-one adults with type 2 diabetes (63 ± 13 years old, BMI 32.4 ± 7 kg/m2, HbA1c 7.5 ± 3.4% [59 ± 14 mmol/mol]) commenced the trial; 28 (90%) completed both interventions. The increase in alkylresorcinols did not differ between interventions, and there was no difference in reported energy intake. Postprandial responses were 9% (95% CI 3-15) lower following breakfast and 6% (1-10) lower following all meals of less-processed whole grains when compared with finely milled grains. Day-long glycemic variability also was reduced when measured by 24-h SD (-0.16 mmol/L [95% CI -0.25 to -0.06]) and mean amplitude of glycemic excursion (-0.36 [95% CI -0.65 to -0.08]). Mean change in body weight differed by 0.81 kg (95% CI 0.62-1.05) between interventions, increasing during the finely milled intervention and decreasing during the less-processed whole-grain intervention. This was not a mediating factor for the glycemic variables considered.
Conclusions
Consuming less-processed whole-grain foods over 2 weeks improved measures of glycemia in free-living adults with type 2 diabetes compared with an equivalent amount of whole-grain foods that were finely milled. Dietary advice should promote the consumption of minimally processed whole grains.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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