The expression of opsins in the human skin and its implications for photobiomodulation: A Systematic Review
Suh S, Choi EH, Atanaskova Mesinkovska N
Photodermatology, photoimmunology & photomedicine · 55 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Eye Institute
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- Center for Scientific Review
- Gobierno
- CSR NIH HHS
- Gobierno
- NEI NIH HHS
- Gobierno
- NIGMS NIH HHS
- Subvenciones
- National Eye Institute (F30EY029136); Center for Scientific Review (F30EY029136); National Institute of General Medical Sciences (T32GM007250); National Eye Institute (T32EY024236); Center for Scientific Review (T32EY024236); Center for Scientific Review (T32GM007250); National Institutes of Health (T32‐GM007250); National Institutes of Health (F30EY029136); National Institutes of Health (T32EY024236)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2020-05-20 · Photodermatol Photoimmunol Photomed · vol. 36 · número 5 · págs. 329–338
- Editorial
- Wiley
- Citado
- 76 citas · más que el 88% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 65 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Dermatologic Treatments and Research · Skin Protection and Aging
- Palabras clave
- Opsin, Biology, Zebrafish, Neuroscience, Dermatology, Evolutionary biology, Medicine, Genetics, Rhodopsin, Retinal
- MeSH
- skin, animals, humans, opsins
3 autores
- Susie Suh🇺🇸University of California, Irvine; Case Western Reserve University
- Elliot H. Choi🇺🇸University of California, Irvine; Case Western Reserve University
- Natasha Atanaskova Mesinkovska🇺🇸 · autor de correspondenciaUniversity of California, Irvine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Skin is the organ most extensively exposed to light of a broad range of wavelengths. Several studies have reported that skin expresses photoreceptive molecules called opsins. However, the identity and functional role of opsins in the human skin remain elusive. We aim to summarize current scientific evidence on the types of opsins expressed in the skin and their biological functions.
Methods
A primary literature search was conducted using PubMed to identify articles on dermal opsins found in nonhuman animals and humans.
Results
Twenty-two articles, representing, however, a non-exhaustive selection of the scientific papers published in this specific field, met the inclusion criteria. In nonhuman animals, opsins and opsin-like structures have been detected in the skin of fruit fly, zebrafish, frog, octopus, sea urchin, hogfish, and mouse, and they mediate skin color change, light avoidance, shadow reflex, and circadian photoentrainment. In humans, opsins are present in various skin cell types, including keratinocytes, melanocytes, dermal fibroblasts, and hair follicle cells. They have been shown to mediate wound healing, melanogenesis, hair growth, and skin photoaging.
Conclusion
Dermal opsins have been identified across many nonhuman animals and humans. Current evidence suggests that opsins have biological significance beyond light reception. In nonhuman animals, opsins are involved in behaviors that are critical for survival. In humans, opsins are involved in various functions of the skin although the underlying molecular mechanisms remain unclear. Future investigation on elucidating the mechanism of dermal opsins will be crucial to expand the therapeutic benefits of photobiomodulation for various skin disorders.
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