Intermittent Fasting Does Not Uniformly Impact Genes Involved in Circadian Regulation in Women with Obesity
Zhao L, Hutchison AT, Wittert GA, Thompson CH, Lange K, Liu B, Heilbronn LK
Obesity (Silver Spring, Md.) · 7 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Adelaide
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- National Health and Medical Research Council (1023401); Medical Research Council (APP1023401)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2020-05-21 · Obesity (Silver Spring) · vol. 28 · número S1 · págs. S63–S67
- Editorial
- Wiley
- Citado
- 8 citas · más que el 67% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Sleep and Work-Related Fatigue
- Palabras clave
- intermittent fasting, circadian regulation, clock genes, women, skeletal muscle, subcutaneous adipose tissue, Per2, RORα, refeeding, circadian misalignment
- MeSH
- muscle, skeletal, animals, humans, obesity, fasting, circadian rhythm, adult, aged, middle aged, female, subcutaneous fat, circadian clocks
7 autores
- Lijun Zhao🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Amy T. Hutchison🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Gary Wittert🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Campbell Henry Thompson🇦🇺The University of Adelaide
- Kylie M. Lange🇦🇺The University of Adelaide
- Bo Liu🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Leonie Kaye Heilbronn🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study aimed to examine the effects of intermittent fasting (IF) on mRNA levels of peripheral clock genes in skeletal muscle and subcutaneous adipose tissue (SAT) in women with obesity.
Methods
Women were randomized to one of two IF protocols and provided with all foods at 100% or 70% of calculated weekly energy requirements for 8 weeks. Breakfast was consumed before a 24-hour fast, which was initiated on three nonconsecutive days per week. Muscle and SAT biopsies were performed at 8 am after an overnight fast at baseline and at week 8 on a refed day and again following a 24-hour fast at week 8 for analysis of the mRNA levels of key genes involved in circadian regulation.
Results
A group-by-time interaction was observed in Per2 in muscle (F = 3.497, P = 0.044) and SAT (F = 6.686, P = 0.008), but significance was lost upon post hoc adjustment. A time effect was observed in Rorα in muscle, which was decreased by refeeding in both groups (F = 7.225, P = 0.003).
Conclusions
There was no universal effect of IF to alter peripheral clocks, which may be partly because of the alignment of the fasting/feeding cycle with the biological clock. Optimizing intermittent fasting protocols could be important to prevent circadian misalignment in humans.
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