Guanidinoacetic acid loading for improved location-specific brain creatine
Ostojic SM
Clinical nutrition (Edinburgh, Scotland) · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Gobierno
- Provincial Secretariat for Science and Technological Development
- Universidad u hospital
- Physical Education and Sport Sciences Department, University of Limerick
- Gobierno
- Ministry of Education, Science and Technological Development
- Gobierno
- Provincial Secretariat for Higher Education and Scientific Research
- Universidad u hospital
- Faculty of Sport and Physical Education
- Subvenciones
- Provincial Secretariat for Science and Technological Development (114–451-710); Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (175037)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2020-05-10 · Clin Nutr · vol. 40 · número 1 · págs. 324–326
- Editorial
- Elsevier BV
- Citado
- 10 citas · más que el 60% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 13 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Advanced MRI Techniques and Applications · Biochemical effects in animals
- Palabras clave
- guanidinoacetic acid, creatine supplementation, cerebellum, white matter, grey matter, thalamus, creatine loading, brain bioenergetics, healthy young men
- MeSH
- brain, cerebellum, thalamus, humans, creatine, glycine, magnetic resonance spectroscopy, energy metabolism, dietary supplements, male, young adult, healthy volunteers, white matter, gray matter
1 autor
- Sergej M. Ostojić🇷🇸🇭🇺 · autor de correspondenciaUniversity of Novi Sad; University of Pecs
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
We conducted here a secondary analysis of previously completed guanidinoacetic acid (GAA) loading trials categorizing participants into responders and non-responders using cut-off points for an increase in the location-specific levels of brain creatine (e.g. thalamus, cerebellum, white and grey matter).
Methods
A total of 19 healthy men (mean age = 24.8 years) who were supplemented with 3 g/d of GAA for 4 weeks, with total brain creatine evaluated using 1.5 T magnetic resonance spectroscopy (MRS) were included in this report.
Results
An average elevation in total creatine content after 28-day GAA loading was 17.3% in the cerebellum (95% confidence interval [CI] from 9.7 to 24.9), 12.1% in the white matter (95% CI from 5.1 to 19.1), and 8.9% in the grey matter (95% CI from 5.2 to 12.6), while total creatine actually dropped in the thalamus at a follow-up for 9.1% (95% CI from 6.8 to 11.4). The prevalence of responders was the highest for the cerebellum (73.6%), followed by the white matter (47.3%) and the grey matter (42.1%), while only two individuals (10.5%) experienced a relevant rise in the thalamus creatine content at 28-day follow-up (P < 0.001).
Conclusion
This aftermath evaluation of previously published data suggests a relatively favorable (and location-specific) response rate to short-term GAA loading in healthy young men. A somewhat contrasting location-dependent pattern for GAA and creatine to positively affect brain creatine may be of great interest to the scientific community by dispensing different interventions to tackle poor bioenergetics in distinct brain regions.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.