An extra virgin olive oil-enriched diet improves maternal, placental, and cord blood parameters in GDM pregnancies
Gomez Ribot D, Diaz E, Fazio MV, Gómez HL, Fornes D, Macchi SB, Gresta CA, Capobianco E, Jawerbaum A
Diabetes/metabolism research and reviews · 29 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Agencia Nacional de Promoción Científica y Tecnológica
- Gobierno
- Agencia Nacional de Promoción Científica y Tecnológica de Argentina
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-05-24 · Diabetes Metab Res Rev · vol. 36 · número 8 · pág. e3349
- Editorial
- Wiley
- Citado
- 30 citas · más que el 88% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Gestational Diabetes Research and Management · Pregnancy and preeclampsia studies · Birth, Development, and Health
- Palabras clave
- gestational diabetes mellitus, extra virgin olive oil, dietary intervention, placenta, umbilical cord blood, pro-inflammatory markers, PPARα, PPARγ, miR-130a, matrix metalloproteinases, MMP-9, triglyceridemia, gestational weight gain, anti-inflammatory activity
- MeSH
- fetal blood, placenta, humans, diabetes, gestational, blood glucose, prognosis, diet, case-control studies, follow-up studies, pregnancy, adult, female, biomarkers, olive oil, glycated hemoglobin
9 autores
- Dalmiro Gómez Ribot🇦🇷Consejo Nacional de Investigaciones Científicas y Técnicas; Universidad de Buenos Aires
- Esteban Díaz
- María Victoria Fazio
- Hebe Lorena Gómez
- Daiana Debora Fornes🇦🇷Consejo Nacional de Investigaciones Científicas y Técnicas; Universidad de Buenos Aires
- Silvia Beatriz Macchi
- Carlos Alberto Gresta
- Evangelina Capobianco🇦🇷Consejo Nacional de Investigaciones Científicas y Técnicas; Universidad de Buenos Aires
- Alicia Jawerbaum🇦🇷 · autor de correspondenciaConsejo Nacional de Investigaciones Científicas y Técnicas; Universidad de Buenos Aires
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To address the effect of a diet enriched in extra virgin olive oil (EVOO) on maternal metabolic parameters and placental proinflammatory markers in Gestational diabetes mellitus (GDM) patients.
Methods
Pregnant women at 24-28 weeks of gestation were enrolled: 33 GDM patients which were randomly assigned or not to the EVOO-enriched group and 17 healthy controls. Metabolic parameters were determined. Peroxisome proliferator activated receptor (PPAR) γ and PPARα protein expression, expression of microRNA (miR)-130a and miR-518d (which respectively target these PPAR isoforms) and levels of proinflammatory markers were evaluated in term placentas. Matrix metalloproteinases (MMPs) activity was evaluated in term placentas and umbilical cord blood.
Results
GDM patients that received the EVOO-enriched diet showed reduced pregnancy weight gain (GDM-EVOO:10.3 ± 0.9, GDM:14.2 ± 1.4, P = .03) and reduced triglyceridemia (GDM-EVOO:231 ± 14, GDM:292 ± 21, P = .02) compared to the non-EVOO-enriched GDM group. In GDM placentas, the EVOO-enriched diet did not regulate PPARγ protein expression or miR-130a expression, but prevented the reduced PPARα protein expression (P = .02 vs GDM) and the increased miR-518d expression (P = .009 vs GDM). Increased proinflammatory markers (interleukin-1β, tumour necrosis factor-α and nitric oxide overproduction) in GDM placentas were prevented by the EVOO-enriched diet (respectively P = .001, P = .001 and P = .01 vs GDM). MMPs overactivity was prevented in placenta and umbilical cord blood in the EVOO-enriched GDM group (MMP-9: respectively P = .01 and P = .001 vs GDM).
Conclusions
A diet enriched in EVOO in GDM patients reduced maternal triglyceridemia and weight gain and has antiinflammatory properties in placenta and umbilical cord blood, possibly mediated by the regulation of PPAR pathways.
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