Egg consumption and risk of type 2 diabetes: findings from 3 large US cohort studies of men and women and a systematic review and meta-analysis of prospective cohort studies
Drouin-Chartier JP, Schwab AL, Chen S, Li Y, Sacks FM, Rosner B, Manson JE, Willett WC, Stampfer MJ, Hu FB, Bhupathiraju SN
The American journal of clinical nutrition · 34 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIH
- Gobierno
- NCI NIH HHS
- Gobierno
- Nurses’ Health Study II
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Sin clasificar
- Health Professionals Follow-up Study
- Gobierno
- Nurses’ Health Study
- Subvenciones
- National Cancer Institute (U01 CA167552); National Heart, Lung, and Blood Institute (U01 HL145386); National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK107804); National Cancer Institute (UM1 CA186107); National Cancer Institute (U01 CA176726); National Cancer Institute (UM1 CA176726); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200); National Cancer Institute (UM1CA167552); National Institutes of Health (U01-CA167552); National Institutes of Health (UM1 CA 176726); National Institutes of Health (U01 HL-145386); National Institutes of Health (U01-CA176726); National Institutes of Health (UM1‐CA‐186107); National Institutes of Health (DK112940)
Según 11 financiadores declarados.
Publicación
- Publicado
- 2020-04-29 · Am J Clin Nutr · vol. 112 · número 3 · págs. 619–630
- Editorial
- Elsevier BV
- Citado
- 46 citas · más que el 82% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 64 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Diet, Metabolism, and Disease · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- egg consumption, type 2 diabetes, diabetes risk, dietary intake, Nurses' Health Study, Health Professionals Follow-up Study, regional variation, dietary fat, dietary fiber, dietary sodium, dietary protein, dietary cholesterol
- MeSH
- humans, diabetes mellitus, type 2, diet, health surveys, risk assessment, cohort studies, eggs, united states, asia, europe, female, male
11 autores
- Jean‐Philippe Drouin‐Chartier🇺🇸🇨🇦 · autor de correspondenciaHarvard University; Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre Nutrition, santé et société
- Amanda L Schwab🇺🇸Harvard University
- Siyu Chen🇺🇸Harvard University
- Yanping Li🇺🇸Harvard University
- Frank M. Sacks🇺🇸Brigham and Women's Hospital; Harvard University
- BERNARD A. ROSNER🇺🇸Brigham and Women's Hospital; Harvard University
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Meir J. Stampfer🇺🇸Brigham and Women's Hospital; Harvard University
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Frank B. Hu🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Whether egg consumption is associated with the risk of type 2 diabetes (T2D) remains unsettled.
Objectives
We evaluated the association between egg consumption and T2D risk in 3 large US prospective cohorts, and performed a systematic review and meta-analysis of prospective cohort studies.
Methods
We followed 82,750 women from the Nurses' Health Study (NHS; 1980-2012), 89,636 women from the NHS II (1991-2017), and 41,412 men from the Health Professionals Follow-up Study (HPFS; 1986-2016) who were free of T2D, cardiovascular disease, and cancer at baseline. Egg consumption was assessed every 2-4 y using a validated FFQ. We used Cox proportional hazard models to estimate HRs and 95% CIs.
Results
During a total of 5,529,959 person-years of follow-up, we documented 20,514 incident cases of T2D in the NHS, NHS II, and HPFS. In the pooled multivariable model adjusted for updated BMI, lifestyle, and dietary confounders, a 1-egg/d increase was associated with a 14% (95% CI: 7%, 20%) higher T2D risk. In random-effects meta-analysis of 16 prospective cohort studies (589,559 participants; 41,248 incident T2D cases), for each 1 egg/d, the pooled RR of T2D was 1.07 (95% CI: 0.99, 1.15; I2 = 69.8%). There were, however, significant differences by geographic region (P for interaction = 0.01). Each 1 egg/d was associated with higher T2D risk among US studies (RR: 1.18; 95% CI: 1.10, 1.27; I2 = 51.3%), but not among European (RR: 0.99; 95% CI: 0.85, 1.15; I2 = 73.5%) or Asian (RR: 0.82; 95% CI: 0.62, 1.09; I2 = 59.1%) studies.
Conclusions
Results from the updated meta-analysis show no overall association between moderate egg consumption and risk of T2D. Whether the heterogeneity of the associations among US, European, and Asian cohorts reflects differences in egg consumption habits warrants further investigation.This systematic review was registered at www.crd.york.ac.uk/prospero as CRD42019127860.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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