Financiado en parte por Egg Nutrition Center
Whole egg consumption increases plasma choline and betaine without affecting TMAO levels or gut microbiome in overweight postmenopausal women
Zhu C, Sawrey-Kubicek L, Bardagjy AS, Houts H, Tang X, Sacchi R, Randolph JM, Steinberg FM, Zivkovic AM
Nutrition research (New York, N.Y.) · 38 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Grupo de la industria
- Egg Nutrition Center
- Universidad u hospital
- West Coast Metabolomics Center, University of California, Davis
Según 3 financiadores declarados.
Publicación
- Publicado
- 2020-04-22 · Nutr Res · vol. 78 · págs. 36–41
- Editorial
- Elsevier BV
- Citado
- 53 citas · más que el 91% de estudios similares · 2.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Gut microbiota and health · Folate and B Vitamins Research · Diet and metabolism studies
- Palabras clave
- Betaine, Trimethylamine N-oxide, Choline, Microbiome, Gut flora, Yolk, Lachnospiraceae, Trimethylamine, Endocrinology, Internal medicine, Overweight, Biology, Physiology, Chemistry, Food science, Medicine, Biochemistry, Obesity, Firmicutes, Bioinformatics
- MeSH
- feces, humans, bacteria, obesity, choline, betaine, methylamines, diet, cross-over studies, postmenopause, eggs, aged, middle aged, female, overweight, gastrointestinal microbiome
9 autores
- Chenghao Zhu🇺🇸University of California, Davis
- Lisa Sawrey‐Kubicek🇺🇸University of California, Davis
- Allison S. Bardagjy🇺🇸University of California, Davis
- Hannah Houts🇺🇸University of California, Davis
- Xinyu Tang🇺🇸University of California, Davis
- Romina Sacchi🇺🇸University of California, Davis
- Jody Randolph🇺🇸University of California, Davis
- Francene M. Steinberg🇺🇸University of California, Davis
- Angela M. Zivkovic🇺🇸 · autor de correspondenciaUniversity of California System; University of California, Davis
Resumen
El texto original del estudio, en el idioma en que se publicó.
As a crucial part of the symbiotic system, the gut microbiome is metabolically connected to many diseases and conditions, including cardiovascular diseases (CVD). Trimethylamine (TMA) is produced by gut bacteria from dietary choline, betaine, or L-carnitine, and is then converted in the liver to Trimethylamine N-oxide (TMAO), which in turn affects hepatic and intestinal lipid metabolism. Circulating TMAO is positively associated with CVD risk. Because eggs are rich in choline, it has been speculated that their consumption may increase plasma TMAO. In this study, we hypothesized that 2 eggs per day increases plasma TMAO level by altering gut microbiome composition in mildly hypercholesterolemic postmenopausal women. In this randomized, cross-over study, 20 overweight, postmenopausal women were given 2 whole eggs and the equivalent amount of yolk-free substitute as breakfast for 4 weeks, in randomized order, with a 4-week washout in between. Fasting blood draws and stool were collected at the beginning and end of each treatment period. Plasma TMAO, choline, betaine and other metabolites were analyzed using LC/MS, while gut microbiome composition was analyzed using 16S amplicon sequencing. Plasma choline and betaine were significantly increased after whole egg but not yolk-free substitute, however TMAO level was not significantly affected by treatments. Gut microbiome composition showed large inter-individual variability at baseline and in response to the treatments. The consumption of 2 eggs per day in overweight, postmenopausal mildly hypercholesterolemic women significantly increased plasma choline and betaine, but did not increase plasma TMAO or alter gut microbiome composition.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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