Financiado en parte por 3M
A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood
Wedekind R, Kiss A, Keski-Rahkonen P, Viallon V, Rothwell JA, Cross AJ, Rostgaard-Hansen AL, Sandanger TM, Jakszyn P, Schmidt JA, Pala V, Vermeulen R, Schulze MB, Kühn T, Johnson T, Trichopoulou A, Peppa E, La Vechia C, Masala G, Tumino R, Sacerdote C, Wittenbecher C, de Magistris MS, Dahm CC, Severi G, Mancini FR, Weiderpass E, Gunter MJ, Huybrechts I, Scalbert A
The American journal of clinical nutrition · 35 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- 3M
- Gobierno
- World Health Organization
- Universidad u hospital
- Centre International de Recherche sur le Cancer
- Gobierno
- National Research Council Sri Lanka
- Organización sin fines de lucro
- Cancer Research UK
- Gobierno
- Bundesministerium für Bildung und Forschung
- Organización sin fines de lucro
- Mutuelle Générale de l'Education Nationale
- Organización sin fines de lucro
- Hellenic Health Foundation
- Gobierno
- International Agency for Research on Cancer
- Organización sin fines de lucro
- Mutuelle Générale de l'Education Nationale
- Organización sin fines de lucro
- Deutsche Krebshilfe, Deutsches Krebsforschungszentrum
- Gobierno
- Federal Ministry of Education and Research
- Gobierno
- Institut National de la Santé et de la Recherche Medicale
- Organización sin fines de lucro
- Italian Association for Research on Cancer
- Gobierno
- National Research Council
- Organización sin fines de lucro
- stipend of La Ligue Nationale contre le Cancer
- Subvenciones
- Cancer Research UK (25004)
Según 16 financiadores declarados.
Publicación
- Publicado
- 2020-05-16 · Am J Clin Nutr · vol. 112 · número 2 · págs. 381–388
- Editorial
- Elsevier BV
- Citado
- 43 citas · más que el 95% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Metabolomics and Mass Spectrometry Studies · Fatty Acid Research and Health
- Palabras clave
- acylcarnitines, red meat consumption, processed meat intake, pork, tofu, fatty acid metabolism, plasma carnitine, dietary intervention, chronic disease risk
- MeSH
- animals, swine, humans, carnitine, prospective studies, cross-sectional studies, meat products, adult, female, male, metabolomics
30 autores
- Roland Wedekind🇫🇷Centre international de recherche sur le cancer
- Agnèta Kiss🇫🇷Centre international de recherche sur le cancer
- Pekka Keski‐Rahkonen🇫🇷Centre international de recherche sur le cancer
- Vivian Viallon🇫🇷Centre international de recherche sur le cancer
- Joseph A. Rothwell🇫🇷Inserm; Université Paris-Saclay; Institut Gustave Roussy; Centre de recherche en Epidémiologie et Santé des Populations
- Amanda Jane Cross🇬🇧Imperial College London
- Agnetha Linn Rostgaard‐Hansen🇩🇰Danish Cancer Society
- Torkjel Manning Sandanger🇳🇴UiT The Arctic University of Norway
- Paula Gabriela Jakszyn🇪🇸Institut Català d'Oncologia; Universitat Ramon Llull
- Julie A. Schmidt🇬🇧University of Oxford
- Valeria Maria Pala🇮🇹Fondazione IRCCS Istituto Nazionale dei Tumori
- Roel C.H. Vermeulen🇳🇱Utrecht University
- Matthias Bernd Schulze🇩🇪University of Potsdam; German Institute of Human Nutrition
- Tilman E. Kuhn🇩🇪German Cancer Research Center
- Theron Johnson🇩🇪German Cancer Research Center
- Antonia Trichopoulou🇬🇷Hellenic Health Foundation
- Eleni Peppa🇬🇷Hellenic Health Foundation
- Carlo La Vechia🇮🇹🇬🇷University of Milan; Hellenic Health Foundation
- Giovanna Masala
- Rosario Tumino
- Carlotta Sacerdote🇮🇹Piedmont Reference Center for Epidemiology and Cancer Prevention
- Clemens Wittenbecher🇺🇸🇩🇪Harvard University; German Center for Diabetes Research; German Institute of Human Nutrition
- Maria Santucci de Magistris🇮🇹Federico II University Hospital
- Christina Catherine Dahm🇩🇰Aarhus University
- Gianluca Severi🇫🇷🇮🇹Inserm; Université Paris-Saclay; Institut Gustave Roussy; Centre de recherche en Epidémiologie et Santé des Populations; University of Florence
- Francesca Romana Mancini🇫🇷Inserm; Université Paris-Saclay; Institut Gustave Roussy; Centre de recherche en Epidémiologie et Santé des Populations
- Elisabete Weiderpass🇫🇷Centre international de recherche sur le cancer
- Marc James Gunter🇫🇷Centre international de recherche sur le cancer
- Inge Huybrechts🇫🇷Centre international de recherche sur le cancer
- Augustin Scalbert🇫🇷Centre international de recherche sur le cancer
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Acylcarnitines (ACs) play a major role in fatty acid metabolism and are potential markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic individuals. Diet, and in particular red and processed meat intake, has been shown to influence AC concentrations but data on the effect of meat consumption on AC concentrations is limited.
Objectives
To investigate the effect of red and processed meat intake on AC concentrations in plasma and urine using a randomized controlled trial with replication in an observational cohort.
Methods
In the randomized crossover trial, 12 volunteers successively consumed 2 different diets containing either pork or tofu for 3 d each. A panel of 44 ACs including several oxidized ACs was analyzed by LC-MS in plasma and urine samples collected after the 3-d period. ACs that were associated with pork intake were then measured in urine (n = 474) and serum samples (n = 451) from the European Prospective Investigation into Cancer and nutrition (EPIC) study and tested for associations with habitual red and processed meat intake derived from dietary questionnaires.
Results
In urine samples from the intervention study, pork intake was positively associated with concentrations of 18 short- and medium-chain ACs. Eleven of these were also positively associated with habitual red and processed meat intake in the EPIC cross-sectional study. In blood, C18:0 was positively associated with red meat intake in both the intervention study (q = 0.004, Student's t-test) and the cross-sectional study (q = 0.033, linear regression).
Conclusions
AC concentrations in urine and blood were associated with red meat intake in both a highly controlled intervention study and in subjects of a cross-sectional study. Our data on the role of meat intake on this important pathway of fatty acid and energy metabolism may help understanding the role of red meat consumption in the etiology of some chronic diseases. This trial was registered at Clinicaltrials.gov as NCT03354130.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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