Higher ultra-processed food intake is associated with higher DNA damage in healthy adolescents
Edalati S, Edalati S, Bagherzadeh F, Asghari Jafarabadi M, Ebrahimi-Mamaghani M
The British journal of nutrition · 38 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tabriz University of Medical Sciences
- Universidad u hospital
- University of Tabriz
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-06-09 · Br J Nutr · vol. 125 · número 5 · págs. 568–576
- Editorial
- Cambridge University Press
- Citado
- 47 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 109 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Obesity, Physical Activity, Diet
- Palabras clave
- Medicine, Confounding, Creatinine, Environmental health, Obesity, Food group, Urinary system, Mediterranean diet, Biomarker, Food science, Internal medicine, Biology
- MeSH
- humans, obesity, dna damage, body mass index, diet, sex factors, energy intake, food handling, adolescent, iran, female, male, young adult, biomarkers, edible grain, 8-hydroxy-2'-deoxyguanosine
4 autores
- Sareh Edalati🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Farzaneh Bagherzadeh🇮🇷Tabriz University of Medical Sciences
- Mohammad Asghari Jafarabadi🇮🇷Tabriz University of Medical Sciences
- Mehrangiz Ebrahimi‐Mameghani🇮🇷 · autor de correspondenciaTabriz University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Ultra-processed food is one of the main contributors to energy supply and consumption in food systems worldwide, and evidence of their detrimental health outcomes in humans is emerging. This study aimed to assess ultra-processed food intake and its association with urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage, in 139 healthy adolescents in Karaj City in Iran. Usual dietary intake was measured using a 168-item validated FFQ. The daily intake of ultra-processed food consumption was determined through the classification of NOVA, and general linear models were used to compare the urinary levels of 8-OHdG/creatinine (ng/mg creatinine) within tertiles of ultra-processed food intake. Adolescents in the higher tertile of ultra-processed food consumption had a significantly higher mean level of urinary 8-OHdG/creatinine in comparison with the lower tertiles in the crude model (Pfor trend: 0·003) and after adjustment for confounding variables, including total energy intake, sex, age, BMI for age Z-score, obesity and physical activity (Pfor trend: 0·004). This association was still significant after adjusting for dietary intake of whole grains, nuts, legumes, the ratio of MUFA:SFA (g/d) and Mediterranean dietary score (Pfor trend: 0·002). More studies are needed to explore the determinants of ultra-processed food supply, demand, consumption and health effects; such studies should be applied to develop evidence-informed policies and regulatory mechanisms to improve children's and adolescents' food environment policymaking and legislation with special attention to ultra-processed food.
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