Effect of Magnesium Supplementation on Circulating Biomarkers of Cardiovascular Disease
Alonso A, Chen LY, Rudser KD, Norby FL, Rooney MR, Lutsey PL
Nutrients · 5 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Organización sin fines de lucro
- American Heart Association-American Stroke Association
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (T32HL007779); National Center for Advancing Translational Sciences ((UL1-TR002494)); National Heart, Lung, and Blood Institute (T32-HL-007024); National Heart, Lung, and Blood Institute (K24 HL148521); American Heart Association (16EIA26410001)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2020-06-06 · Nutrients · vol. 12 · número 6 · pág. 1697
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 8 citas · más que el 67% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Iron Metabolism and Disorders
- Palabras clave
- Magnesium, Medicine, Placebo, Confidence interval, Internal medicine, Randomized controlled trial, Gastroenterology, Endocrinology, Chemistry, Pathology
- MeSH
- humans, cardiovascular diseases, magnesium, magnesium oxide, blood proteins, myoglobin, administration, oral, double-blind method, proteomics, dietary supplements, middle aged, female, tumor necrosis factor ligand superfamily member 13, biomarkers, tartrate-resistant acid phosphatase, interleukin-1 receptor-like 1 protein
6 autores
- Álvaro Alonso🇺🇸 · autor de correspondenciaEmory University
- Lin Y. Chen🇺🇸University of Minnesota
- Kyle D. Rudser🇺🇸University of Minnesota
- Faye L. Norby🇺🇸University of Minnesota
- Mary R. Rooney🇺🇸Johns Hopkins University
- Pamela L. Lutsey🇺🇸University of Minnesota
Resumen
El texto original del estudio, en el idioma en que se publicó.
(1) Background: Magnesium supplementation may be effective for the prevention of cardiometabolic diseases, but the mechanisms are unclear. Proteomic approaches can assist in identifying the underlying mechanisms. (2) Methods: We collected repeated blood samples from 52 individuals enrolled in a double-blind trial which randomized participants 1:1 to oral magnesium supplementation (400 mg magnesium/day in the form of magnesium oxide) or a matching placebo for 10 weeks. Plasma levels of 91 proteins were measured at baseline with follow-up samples using the Olink Cardiovascular Disease III proximity extension assay panel and were modeled as arbitrary units in a log2 scale. We evaluated the effect of oral magnesium supplementation for changes in protein levels and the baseline association between serum magnesium and protein levels. The Holm procedure was used to adjust for multiple comparisons. (3) Results: Participants were 73% women, 94% white, and had a mean age of 62. Changes in proteins did not significantly differ between the two intervention groups after correction for multiple comparisons. The most statistically significant effects were on myoglobin [difference -0.319 log2 units, 95% confidence interval (CI) (-0.550, -0.088), p = 0.008], tartrate-resistant acid phosphatase type 5 (-0.187, (-0.328, -0.045), p = 0.011), tumor necrosis factor ligand superfamily member 13B (-0.181, (-0.332, -0.031), p = 0.019), ST2 protein (-0.198, (-0.363, -0.032), p = 0.020), and interleukin-1 receptor type 1 (-0.144, (-0.273, -0.015), p = 0.029). Similarly, none of the associations of baseline serum magnesium with protein levels were significant after correction for multiple comparisons. (4) Conclusions: Although we did not identify statistically significant effects of oral magnesium supplementation in this relatively small study, this study demonstrates the value of proteomic approaches for the investigation of mechanisms underlying the beneficial effects of magnesium supplementation. Clinical Trials Registration: ClinicalTrials.gov NCT02837328.
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