Anti-Inflammatory Potential of n-3 Polyunsaturated Fatty Acids Enriched Hen Eggs Consumption in Improving Microvascular Endothelial Function of Healthy Individuals-Clinical Trial
Stupin A, Mihalj M, Kolobarić N, Šušnjara P, Kolar L, Mihaljević Z, Matić A, Stupin M, Jukić I, Kralik Z, Grčević M, Kralik G, Šerić V, Drenjančević I
International journal of molecular sciences · 30 citas
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- Ensayo clínico controlado (indexado por PubMed)
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- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Structural and Investment Funds grant for the Croatian National Scientific Center of Excellence for Personalized Health Care, University of Josip Juraj Strossmayer Osijek
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-06-10 · Int J Mol Sci · vol. 21 · número 11 · pág. 4149
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 40 citas · más que el 90% de estudios similares · 2.9× el promedio de su campo
- Referencias
- 74 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Polyunsaturated fatty acid, Endothelium, Endocrinology, Internal medicine, Endothelial activation, Inflammation, Endothelial dysfunction, Microcirculation, Vasodilation, Sodium nitroprusside, Medicine, Chemistry, Nitric oxide, Biochemistry, Fatty acid
- MeSH
- endothelium, vascular, microcirculation, skin, animals, chickens, humans, fatty acids, omega-3, fatty acids, anti-inflammatory agents, non-steroidal, anti-inflammatory agents, cytokines, blood chemical analysis, body composition, vasodilation, eggs, food, fortified, adult, female, male, hemodynamics, young adult
14 autores
- Ana Stupin🇭🇷University of Osijek
- Martina Mihalj🇭🇷University of Osijek
- Nikolina Kolobarić🇭🇷University of Osijek
- Petar Šušnjara🇭🇷University of Osijek
- Luka Kolar🇭🇷Polytechnic Lavoslav Ružička Vukovar; University of Osijek
- Zrinka Mihaljević🇭🇷University of Osijek
- Anita Matić🇭🇷University of Osijek
- Marko Stupin🇭🇷University of Osijek
- Ivana Jukić🇭🇷University of Osijek
- Zlata Kralik🇭🇷University of Osijek
- Manuela Grčević🇭🇷University of Osijek
- Gordana Kralik🇭🇷University of Osijek
- Vatroslav Šerić🇭🇷University of Osijek
- Ines Drenjančević🇭🇷 · autor de correspondenciaUniversity of Osijek
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effects of consumption of n-3 polyunsaturated fatty acids (n-3 PUFAs) enriched hen eggs on endothelium-dependent and endothelium-independent vasodilation in microcirculation, and on endothelial activation and inflammation were determined in young healthy individuals. Control group (N = 21) ate three regular hen eggs/daily (249 mg n-3 PUFAs/day), and n-3 PUFAs group (N = 19) ate three n-3 PUFAs enriched hen eggs/daily (1053 g n-3 PUFAs/day) for 3 weeks. Skin microvascular blood flow in response to iontophoresis of acetylcholine (AChID; endothelium-dependent) and sodium nitroprusside (SNPID; endothelium-independent) was assessed by laser Doppler flowmetry. Blood pressure (BP), body composition, body fluid status, serum lipid and free fatty acids profile, and inflammatory and endothelial activation markers were measured before and after respective dietary protocol. Results: Serum n-3 PUFAs concentration significantly increased, AChID significantly improved, and SNPID remained unchanged in n-3 PUFAs group, while none was changed in Control group. Interferon-γ (pro-inflammatory) significantly decreased and interleukin-10 (anti-inflammatory) significantly increased in n-3 PUFAs. BP, fat free mass, and total body water significantly decreased, while fat mass, interleukin-17A (pro-inflammatory), interleukin-10 and vascular endothelial growth factor A significantly increased in the Control group. Other measured parameters remained unchanged in both groups. Favorable anti-inflammatory properties of n-3 PUFAs consumption potentially contribute to the improvement of microvascular endothelium-dependent vasodilation in healthy individuals.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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