The Relation between Red Meat and Whole-Grain Intake and the Colonic Mucosal Barrier: A Cross-Sectional Study
Jawhara M, Sørensen SB, Heitmann BL, Halldórsson ÞI, Pedersen AK, Andersen V
Nutrients · 2 citas
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Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Aarhus Universitet
- Universidad u hospital
- Aarhus Universitetshospital
- Gobierno
- European Commission
- Universidad u hospital
- Syddansk Universitet
- Organización sin fines de lucro
- Knud og Edith Eriksens Mindefond
- Gobierno
- Horizon 2020 Framework Programme
- Gobierno
- Horizon 2020
- Subvenciones
- European Commission (HORIZON2020); Horizon 2020 Framework Programme (733100); European Commission (733100)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-06-12 · Nutrients · vol. 12 · número 6 · pág. 1765
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 4 citas · más que el 56% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Food composition and properties · Probiotics and Fermented Foods
- Palabras clave
- Cross-sectional study, Red meat, Food science, Whole grains, Biology, Medicine, Pathology
- MeSH
- intestinal mucosa, colon, mucus, humans, colonoscopy, biopsy, in situ hybridization, fluorescence, diet, diet surveys, cross-sectional studies, adult, aged, aged, 80 and over, middle aged, denmark, female, male, mucin-2, microbiota, whole grains, red meat
6 autores
- Mohamad Jawhara🇩🇰 · autor de correspondenciaUniversity of Southern Denmark; Sygehus Sønderjylland
- Signe Bek Sørensen🇩🇰University of Southern Denmark
- Berit L. Heitmann🇩🇰🇦🇺University of Copenhagen; The University of Sydney; Frederiksberg Hospital
- Thorhallur Ingi Halldorsson🇩🇰🇮🇸Statens Serum Institut; University of Iceland
- Andreas Kristian Pedersen🇩🇰Sygehus Sønderjylland
- Vibeke Charlotte Andersen🇩🇰University of Southern Denmark
Resumen
El texto original del estudio, en el idioma en que se publicó.
The Colonic Mucosal Barrier (CMB) is the site of interaction between the human body and the colonic microbiota. The mucus is the outer part of the CMB and is considered as the front-line defense of the colon. It separates the host epithelial lining from the colonic content, and it has previously been linked to health and diseases. In this study, we assessed the relationship between red meat and whole-grain intake and (1) the thickness of the colonic mucus (2) the expression of the predominant mucin gene in the human colon (MUC2). Patients referred to colonoscopy at the University Hospital of Southern Denmark- Sonderjylland were enrolled between June 2017 and December 2018, and lifestyle data was collected in a cross-sectional study design. Colonic biopsies, blood, urine, and fecal samples were collected. The colonic mucus and bacteria were visualized by immunostaining and fluorescence in situ hybridization techniques. We found a thinner mucus was associated with high red meat intake. Similarly, the results suggested a thinner mucus was associated with high whole-grain intake, albeit to a lesser extent than red meat. This is the first study assessing the association between red meat and whole-grain intake and the colonic mucus in humans. This study is approved by the Danish Ethics Committee (S-20160124) and the Danish Data Protecting Agency (2008-58-035). A study protocol was registered at clinical trials.gov under NCT04235348.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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