Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α
Yu J, Liu H, He S, Li P, Ma C, Ma M, Liu Y, Lv L, Ping F, Zhang H, Li W, Sun Q, Xu L, Li Y
Mediators of inflammation · 8 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- CAMS Innovation Fund for Medical Sciences
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-05-22 · Mediators Inflamm · vol. 2020 · págs. 1–6
- Editorial
- Hindawi Publishing Corporation
- Citado
- 9 citas · más que el 67% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 20 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Telomeres, Telomerase, and Senescence · Biomarkers in Disease Mechanisms · Nutrition and Health in Aging
- Palabras clave
- Medicine, Internal medicine, Odds ratio, Confidence interval, Endocrinology, Quartile, Magnesium, Chemistry
- MeSH
- leukocytes, telomere, humans, diabetes mellitus, type 2, inflammation, magnesium, blood glucose, tumor necrosis factor-alpha, anthropometry, diet, odds ratio, regression analysis, cross-sectional studies, oxidative stress, adult, aged, middle aged, female, male, real-time polymerase chain reaction, glycated hemoglobin
14 autores
- Jie Yu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Haibin Liu🇨🇳Capital Medical University
- Shuli He🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Pingping Li🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Chunxiao Ma
- Minglei Ma🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yiwen Liu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Lu Lv🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Fan Ping🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Huabing Zhang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Wei Li🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Qi Sun🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Lingling Xu🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yuxiu Li🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL).
Designs
The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). However, few epidemiological studies have evaluated the effects of magnesium on LTL in the clinical setting. Participants. This cross-sectional analysis included 467 participants (34.8% men). Measurements. Serum blood lipid profile, HbA1c, oxidative stress, and proinflammatory mediator levels were measured. Detailed dietary data were obtained using a 24 h food recall. LTL was assessed using a real-time PCR assay. Regression models and simple regulatory models were used for data analysis.
Results
There was an inverse relationship between dietary magnesium and LTL (P α, with an interquarter difference of 3.79 pmol/mL (P for trend = 0.006). Multivariate regression analysis revealed that the odds ratios (ORs) for shorter LTL and higher serum TNFα increased with magnesium intake, and the ORs of the differences between extreme quartiles were 2.60 (95% confidence interval (CI): 1.31-5.36; P = 0.003) and 1.98 (95% CI: 1.09-3.59; P = 0.008). There was a direct negative effect of dietary magnesium intake on LTL (B = -0.002; P = 0.001), which appeared to be indirectly influenced by TNFα (-0.002 to -0.0005).
Conclusions
Dietary magnesium intake may be a critical component of the cellular aging process, and its effect could be partly mediated by TNFα.
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