Dietary nitrate improves skeletal muscle microvascular oxygenation in HIV-infected patients receiving highly active antiretroviral therapy: a randomised, double-blind, cross-over, placebo-controlled study
Barros-Santos E, de Oliveira GV, Volino-Souza M, Alvares TS
The British journal of nutrition · 6 citas
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- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-06-24 · Br J Nutr · vol. 124 · número 12 · págs. 1277–1284
- Editorial
- Cambridge University Press
- Citado
- 10 citas · más que el 82% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · HIV-related health complications and treatments
- Palabras clave
- dietary nitrate, HIV infection, highly active antiretroviral therapy, muscle oxygen saturation, endothelial dysfunction, handgrip exercise, post-exercise recovery, salivary nitrite, urinary nitrate, exercise fatigue
- MeSH
- muscle, skeletal, endothelial cells, humans, hiv-1, beta vulgaris, hiv infections, nitrates, hand strength, treatment outcome, antiretroviral therapy, highly active, cross-over studies, double-blind method, oxygen consumption, dietary supplements, adult, middle aged, female, male, microvessels, young adult, fruit and vegetable juices
4 autores
- Elisa Barros-Santos🇧🇷Universidade Federal do Rio de Janeiro
- Gustavo Vieira de Oliveira🇧🇷Universidade Federal do Rio de Janeiro
- Mônica Volino‐Souza🇧🇷Universidade Federal do Rio de Janeiro
- Thiago Silveira Álvares🇧🇷 · autor de correspondenciaUniversidade Federal do Rio de Janeiro
Resumen
El texto original del estudio, en el idioma en que se publicó.
HIV-1 proteins and highly active antiretroviral therapy (HAART) have been associated with microvascular endothelial dysfunction. Although nitrate-rich beetroot juice (NR-BJ) consumption has been shown to improve endothelial function in clinical population, its effects in HIV-infected patients has not been addressed. We investigated the effect of a single dose of NR-BJ on muscle oxygen saturation parameters in response to a handgrip exercise in HIV-infected patients. Fifteen HIV-infected patients received NR-BJ or nitrate-depleted beetroot juice (ND-BJ) in a double-blind cross-over design. Near-IR spectroscopy was utilised to assess muscle oxygen saturation parameters during rhythmic handgrip exercise after NR-BJ or ND-BJ supplementation. A significant faster muscle oxygen desaturation rate during exercise (-7·97 (sd 5·00) v. -5·45 (3·94) %/s, P = 0·005) and muscle oxygen resaturation rate during exercise recovery (0·43 (0·24) v. 0·28 (0·24) %/s, P = 0·030) after NR-BJ ingestion was found. However, no significant difference in exercise time until fatigue was observed. Salivary nitrite and urinary nitrate concentration were analysed after NR-BJ or ND-BJ. A significant increase in salivary nitrite and urinary nitrate in NR-BJ was observed compared with ND-BJ (P < 0·05). Our findings suggest that NR-BJ consumption may acutely improve muscle oxygen saturation during exercise and exercise recovery in HIV-infected patients undergoing HAART and who are expected to present microvascular damage. Thus, future studies investigating the chronic effects of NR-BJ are warranted to delineate a better nutritional strategy based on nitrate-rich foods.
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