The Effect of Caffeine on the Risk and Progression of Parkinson's Disease: A Meta-Analysis
Hong CT, Chan L, Bai CH
Nutrients · 76 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-06-22 · Nutrients · vol. 12 · número 6 · pág. 1860
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 114 citas · más que el 95% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Coffee research and impacts · Parkinson's Disease Mechanisms and Treatments · Adenosine and Purinergic Signaling
- Palabras clave
- Caffeine, Medicine, Hazard ratio, Cohort, Internal medicine, Parkinson's disease, Disease, Cohort study, Lower risk, Dyskinesia, Confidence interval
- MeSH
- humans, parkinson disease, disease progression, levodopa, caffeine, proportional hazards models, cohort studies, coffee
3 autores
- Chien‐Tai Hong🇹🇼Taipei Medical University-Shuang Ho Hospital; Taipei Medical University
- Lung Chan🇹🇼 · autor de correspondenciaTaipei Medical University-Shuang Ho Hospital; Taipei Medical University
- Chyi‐Huey Bai🇹🇼 · autor de correspondenciaTaipei Medical University Hospital; Taipei Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Coffee and caffeine are speculated to be associated with the reduced risk of Parkinson's disease (PD). The present study aimed to investigate the disease-modifying potential of caffeine on PD, either for healthy people or patients, through a meta-analysis. The electronic databases were searched using terms related to PD and coffee and caffeinated food products. Articles were included only upon fulfillment of clear diagnostic criteria for PD and details regarding their caffeine content. Reference lists of relevant articles were reviewed to identify eligible studies not shortlisted using these terms. In total, the present study enrolled 13 studies, nine were categorized into a healthy cohort and the rest into a PD cohort. The individuals in the healthy cohort with regular caffeine consumption had a significantly lower risk of PD during follow-up evaluation (hazard ratio (HR) = 0.797, 95% CI = 0.748-0.849, p p = 0.03). In conclusion, caffeine modified disease risk and progression in PD, among both healthy individuals or those with PD. Potential biological benefits, such as those obtained from adenosine 2A receptor antagonism, may require further investigation for designing new drugs.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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