Creatine supplementation improves performance, but is it safe? Double-blind placebo-controlled study
Almeida D, Colombini A, Machado M
The Journal of sports medicine and physical fitness · 14 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-06-01 · J Sports Med Phys Fitness · vol. 60 · número 7 · págs. 1034–1039
- Editorial
- Edizioni Minerva Medica
- Citado
- 31 citas · más que el 77% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Thermoregulation and physiological responses
- Palabras clave
- Creatine, Medicine, Placebo, Creatine Monohydrate, Urine, Renal function, Internal medicine, Placebo-controlled study, Creatinine, Physiology, Double blind, Pathology
- MeSH
- muscle, skeletal, liver, kidney, humans, weight gain, creatine, lipids, hematologic tests, leukocyte count, double-blind method, dietary supplements, adult, male, athletic performance, resistance training, young adult, performance-enhancing substances, biomarkers
3 autores
- Douglas Lopes Almeida
- Alessandra Colombini🇮🇹 · autor de correspondenciaIRCCS Ospedale Galeazzi - Sant'Ambrogio; Istituti di Ricovero e Cura a Carattere Scientifico
- Marco Machado🇧🇷Fundação Universitária de Itaperuna
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Creatine represents a natural supplement and ergogenic aid for sport performance, but there are several concerns regarding its safety for health. The present double-blind placebo-controlled study evaluated the effect of creatine monohydrate supplementation on a panel of blood and urine health indicators in resistance training practitioners.
Methods
Eighteen males performing resistance training three times per week were supplemented with 0.3 g/kg per day creatine monohydrate for 7 days and compared with matched controls supplemented with dextrosol. Blood and urine samples were collected pre- and 30 days post-supplementation to evaluate 41 biochemical parameters and renal function.
Results
Creatine monohydrate supplementation did not cause adverse events and, as expected, promoted an increase of the performance and body weight. No modification of red blood cells parameters, white blood cells profile, blood lipid profile, metabolic and urine markers, hepatic and renal function were observed in the supplemented group.
Conclusions
Despite the expected weight increase, the creatine monohydrate supplementation is safe for health and no detrimental effects on different organs and physiological systems were observed in our cohort of volunteers.
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