Low-level laser therapy in the prevention and treatment of oral mucositis: a systematic review and meta-analysis
Peng J, Shi Y, Wang J, Wang F, Dan H, Xu H, Zeng X
Oral surgery, oral medicine, oral pathology and oral radiology · 21 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Sichuan University
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-06-05 · Oral Surg Oral Med Oral Pathol Oral Radiol · vol. 130 · número 4 · págs. 387–397.e9
- Editorial
- Elsevier BV
- Citado
- 39 citas · más que el 77% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, chemotherapy-induced mucositis, radiotherapy-induced mucositis, mucositis prevention, mucositis treatment, oral pain
- MeSH
- humans, stomatitis, databases, factual, low-level light therapy
7 autores
- Jiakuan Peng🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Sichuan University; State Key Laboratory of Oral Diseases
- Yujie Shi🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Sichuan University; State Key Laboratory of Oral Diseases
- Jiongke Wang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Sichuan University; State Key Laboratory of Oral Diseases
- Fei Wang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Sichuan University; State Key Laboratory of Oral Diseases
- Hongxia Dan🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Sichuan University; State Key Laboratory of Oral Diseases
- Hao Ying Xu🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Sichuan University; State Key Laboratory of Oral Diseases
- Xin Ying Zeng🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Sichuan University; State Key Laboratory of Oral Diseases
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim of this study was to determine whether prophylactic and therapeutic low-level laser therapy (LLLT), compared with placebo or no therapy, reduced the risk of severe oral mucositis (OM) in patients receiving chemotherapy or radiotherapy.
Study design
We searched for articles published on randomized controlled trials (RCTs) in the databases MEDLINE, EMBASE, Cochrane Library, Cochrane Central Register of Controlled Trials, Web of Science, and Clinical Trials, until December 2018. RCTs were filtered on the basis of eligibility criteria, and data were analyzed by using R software 3.5.2.
Results
Overall, 30 studies were included in the meta-analysis. Prophylactic LLLT reduced the overall risk of severe OM (relative risk [RR] = 0.40; 95% confidence interval [CI]: 0.28-0.57; P < .01). Therapeutic LLLT substantially reduced the duration of severe OM (P < .01). LLLT also reduced the overall mean grade of OM, overall incidence of severe pain, mean score of pain, and incidence of severe OM, at the most anticipated time.
Conclusions
Prophylactic and therapeutic LLLT can reduce the risk of severe OM in patients receiving chemotherapy or radiotherapy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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