Photobiomodulation in oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis followed by a cost-effectiveness analysis
Campos TM, do Prado Tavares Silva CA, Sobral APT, Sobral SS, Rodrigues MFSD, Bussadori SK, Fernandes KPS, Mesquita-Ferrari RA, Horliana ACRT, Motta LJ
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 24 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-07-14 · Support Care Cancer · vol. 28 · número 12 · págs. 5649–5659
- Editorial
- Springer Science+Business Media
- Citado
- 35 citas · más que el 76% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- oral mucositis, low-level laser therapy, head and neck cancer, cancer treatment toxicity, analgesia, cost-effectiveness, incremental cost-effectiveness ratio
- MeSH
- humans, head and neck neoplasms, stomatitis, radiation injuries, phototherapy, cost-benefit analysis, randomized controlled trials as topic, laser therapy
10 autores
- Thalita Molinos Campos🇧🇷Universidade Nove de Julho
- Carolina Antunes do Prado Tavares Silva🇧🇷Universidade Nove de Julho
- Ana Paula Taboada Sobral🇧🇷Universidade Nove de Julho
- Sérgio de Sousa Sobral🇧🇷Universidade Nove de Julho
- Maria Fernanda Setúbal Destro Rodrigues🇧🇷Universidade Nove de Julho
- Sandra Kalil Bussadori🇧🇷Universidade Nove de Julho
- Kristianne Porta Santos Fernandes🇧🇷Universidade Nove de Julho
- Raquel Agnelli Mesquita‐Ferrari🇧🇷Universidade Nove de Julho
- Anna Carolina Ratto Tempestini Horliana🇧🇷Universidade Nove de Julho
- Lara Jansiski Motta🇧🇷 · autor de correspondenciaUniversidade Nove de Julho
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Oral mucositis (OM) is an oral toxicity caused by cancer treatment, found often in patients with head and neck cancer. Low-intensity laser therapy for OM has anti-inflammatory, analgesic, and tissue reparative properties.
Objective
The objective of this work is to perform a systematic review and meta-analysis of the randomized clinical trials of OM laser therapy in patients undergoing treatment for head and neck cancers, followed by a cost-effectiveness analysis of the therapy.
Method
The search terms, mucositis and phototherapy, laser therapy and mucositis, photobiomodulation and mucositis, and low-level laser therapy and mucositis, were used to search the databases of PubMed, Web of Science, and MEDLINE. Randomized clinical trials were divided into two groups: one treated with laser therapy and the other given a placebo. Only 13 studies were included in the systematic review, and 6 studies in the meta-analysis.
Results
The results of the systematic review and meta-analysis show that the laser therapy presented good results in clinical improvement and pain reduction, decreasing the patients' likelihood of developing OM, with degrees of debilitating lesions, to 64% (RR = 0.36 [95% CI = 0.29-0.44]). The cost-effectiveness analysis revealed an incremental cost of R$ 3687.53 for the laser group, with an incremental effectiveness of 132.2. The incremental cost-effectiveness ratio (ICER) was 27.89, for the severe OM cases that were avoided.
Conclusion
It was concluded, therefore, that photobiomodulation for OM in patients receiving head and neck cancer treatment was clinically effective and cost-effective.
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