Creatine supplementation does not promote additional effects on inflammation and insulin resistance in older adults: A pilot randomized, double-blind, placebo-controlled trial
Oliveira CLP, Antunes BMM, Gomes AC, Lira FS, Pimentel GD, Boulé NG, Mota JF
Clinical nutrition ESPEN · 11 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- National Council for Scientific and Technological Development
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (305082/2019-1)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-06-23 · Clin Nutr ESPEN · vol. 38 · págs. 94–98
- Editorial
- Elsevier BV
- Citado
- 17 citas · más que el 67% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Nutrition and Health in Aging
- Palabras clave
- creatine supplementation, resistance training, older adults, inflammation, insulin resistance, MCP-1, C-reactive protein, interleukin-6, adiponectin, leptin, low-grade inflammation, age-related chronic diseases
- MeSH
- humans, insulin resistance, inflammation, creatine, pilot projects, body composition, dietary supplements, aged, muscle strength
7 autores
- Camila L. P. Oliveira🇨🇦University of Alberta
- Barbara Moura Antunes🇧🇷Universidade Estadual Paulista (Unesp)
- Aline Corado Gomes🇧🇷Universidade Federal de Goiás
- Fábio Santos Lira🇧🇷Universidade Estadual Paulista (Unesp)
- Gustavo D. Pimentel🇧🇷Universidade Federal de Goiás
- Normand G. Boulé🇨🇦University of Alberta
- João Felipe Mota🇧🇷 · autor de correspondenciaUniversidade Federal de Goiás
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A chronic, low-grade inflammation is commonly present in older adults and has been associated with the onset of age-related chronic diseases. Resistance training (RT) and creatine (CR) supplementation emerged as promising strategies to reduce circulating pro-inflammatory cytokines. This study aimed to investigate the effects of CR supplementation combined with RT on markers of inflammation and insulin resistance in community-dwelling older adults.
Methods
In a pilot randomized, double-blind, placebo-controlled trial, participants were allocated to one of the following groups: 1) Creatine supplementation and resistance training (CR + RT, n = 13); 2) Placebo and resistance training (PL + RT, n = 14). While engaged in a 12-week RT program, participants from CR + RT group received 5 g/day of CR monohydrate and participants from PL + RT group received the same dose of maltodextrin. At baseline and at week 12, blood samples were collected for glucose, insulin, adiponectin, leptin, interleukin 6, interleukin 10, monocyte chemo-attractant protein-1 and C-reactive protein analysis.
Results
After 12 weeks of intervention, there were no differences between groups in any of the variables analyzed. Monocyte chemoattractant protein-1 was reduced in both groups (CR + RT: -55.66 ± 48.93 pg/mL, p < 0.01, dz = 1.13; PL + RT: -46.52 ± 55.21 pg/mL, p < 0.01, dz = 0.84).
Conclusion
Resistance training, regardless of CR supplementation, decreased MCP-1 concentration in older adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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