Association between dietary fat intake and mortality from all-causes, cardiovascular disease, and cancer: A systematic review and meta-analysis of prospective cohort studies
Kim Y, Je Y, Giovannucci EL
Clinical nutrition (Edinburgh, Scotland) · 102 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Science, ICT and Future Planning
- Gobierno
- National Research Foundation of Korea
- Subvenciones
- National Research Foundation of Korea (2018R1D1A1B07045353)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2020-07-14 · Clin Nutr · vol. 40 · número 3 · págs. 1060–1070
- Editorial
- Elsevier BV
- Citado
- 166 citas · más que el 95% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Fatty Acid Research and Health · Nuts composition and effects
- Palabras clave
- dietary fat, saturated fat, trans fatty acids, polyunsaturated fat, monounsaturated fatty acids, all-cause mortality, cardiovascular mortality, cancer mortality, nonlinear relationship, dietary fat intake, energy intake
- MeSH
- humans, neoplasms, cardiovascular diseases, dietary fats, diet, fat-restricted, cause of death, prospective studies, eating, adult, aged, aged, 80 and over, middle aged, female, male, diet, high-fat
3 autores
- Youngyo Kim🇰🇷Gyeongsang National University
- Youjin Je🇰🇷 · autor de correspondenciaKyung Hee University
- Edward L. Giovannucci🇺🇸Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
The association between dietary fat and mortality remains inconsistent, and recent results for the association between dietary saturated fat and chronic disease are controversial. To quantitatively assess this association, we conducted a meta-analysis of prospective cohort studies.
Methods
The PubMed and Web of Science were searched up to February 2020. A random effects model was used.
Results
Nineteen studies including 1,013,273participants and 195,515deaths were identified. Significant inverse associations between all-cause mortality and a 5% energy increment in intakes of total (RR = 0.99; 95% CI:0.98-1.00), monounsaturated (RR = 0.98; 95% CI:0.97-0.99), and polyunsaturated fat (RR = 0.93; 95% CI:0.89-0.97) were found. A 5% increase in energy from polyunsaturated fat was associated with 5% (RR = 0.95; 95% CI:0.91-0.98) and 4% (RR = 0.96; 95% CI:0.94-0.99) lower mortality from CVD and cancer, respectively. A 1% energy increment in dietary trans-fat was associated with 6% higher risk of mortality from all-causes (RR = 1.06; 95% CI:1.01-1.10) and CVD (RR = 1.06; 95% CI:1.02-1.11). We found a non-linear association between dietary saturated fat and all-cause mortality showing a significant increased risk up to 11% of energy from saturated fat intake. The risk of cancer mortality increased by 4% for every 5% increase in energy from saturated fat (RR = 1.04; 95% CI:1.02-1.06).
Conclusions
Diets high in saturated fat were associated with higher mortality from all-causes, CVD, and cancer, whereas diets high in polyunsaturated fat were associated with lower mortality from all-causes, CVD, and cancer. Diets high in trans-fat were associated with higher mortality from all-causes and CVD. Diets high in monounsaturated fat were associated with lower all-cause mortality.
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