ω-6 Polyunsaturated fatty acids (linoleic acid) activate both autophagy and antioxidation in a synergistic feedback loop via TOR-dependent and TOR-independent signaling pathways
Yang B, Zhou Y, Wu M, Li X, Mai K, Ai Q
Cell death & disease · 72 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Karolinska Institutet
- Gobierno
- Agriculture Research System of China
- Gobierno
- Recruitment Program of Global Experts
- Gobierno
- National Science Fund for Distinguished Young Scholars
- Subvenciones
- National Science Fund for Distinguished Young Scholars (31525024); National Natural Science Foundation of China (2018-29); Agriculture Research System of China (2018-29); National Natural Science Foundation of China (31830103); National Natural Science Foundation of China (CARS-47); Agriculture Research System of China (CARS‐47‐11); National Natural Science Foundation of China (31525024); Agriculture Research System of China (CARS47); National Natural Science Foundation of China (47-11)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-07-30 · Cell Death Dis · vol. 11 · número 7 · pág. 607
- Editorial
- Springer Nature
- Citado
- 125 citas · más que el 96% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Autophagy in Disease and Therapy · Alcohol Consumption and Health Effects
- Palabras clave
- Linoleic acid, Cell biology, Polyunsaturated fatty acid, Autophagy, Signal transduction, Chemistry, Biochemistry, TOR signaling, Biology, Fatty acid, Apoptosis
- MeSH
- hepatocytes, animals, perciformes, humans, adenylate kinase, linoleic acid, antioxidants, signal transduction, base sequence, protein binding, dietary supplements, autophagy, nf-e2-related factor 2, promoter regions, genetic, feedback, physiological, hek293 cells, tor serine-threonine kinases, sequestosome-1 protein, kelch-like ech-associated protein 1
6 autores
- Bo Yang🇨🇳Qingdao National Laboratory for Marine Science and Technology; Ministry of Agriculture and Rural Affairs; Ocean University of China
- Yan Zhou🇨🇳Qingdao National Laboratory for Marine Science and Technology; Ministry of Agriculture and Rural Affairs; Ocean University of China
- Mengjiao Wu🇨🇳Qingdao National Laboratory for Marine Science and Technology; Ministry of Agriculture and Rural Affairs; Ocean University of China
- Xueshan Li🇨🇳Qingdao National Laboratory for Marine Science and Technology; Ministry of Agriculture and Rural Affairs; Ocean University of China
- Kangsen Mai🇨🇳Qingdao National Laboratory for Marine Science and Technology; Ministry of Agriculture and Rural Affairs; Ocean University of China
- Qinghui Ai🇨🇳 · autor de correspondenciaQingdao National Laboratory for Marine Science and Technology; Ocean University of China
Resumen
El texto original del estudio, en el idioma en que se publicó.
ω-6 Polyunsaturated fatty acids (PUFAs) are essential fatty acids that participate in macroautophagy (hereafter referred to as autophagy) and the Kelch ECH-associating protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant system in organisms. However, the molecular mechanisms by which ω-6 PUFAs (linoleic acid) regulate autophagy and Keap1-Nrf2 antioxidant system are not completely understood. Therefore, the purposes of this study were to explore the molecular mechanisms by which ω-6 PUFAs (linoleic acid) regulate autophagy and antioxidant system and to investigate the potential relationship between autophagy and antioxidant system through transcriptomic analysis, quantitative real-time polymerase chain reaction (RT-qPCR), western blot analysis, coimmunoprecipitation (Co-IP) and electrophoretic mobility shift assays (EMSAs) in vivo and in vitro. The results of the present study indicated that ω-6 PUFAs in diets induced autophagy but decrease antioxidant ability in vivo. However, the results also provided evidence, for the first time, that ω-6 PUFAs (linoleic acid) induced autophagy and increased antioxidant ability through the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway and the AMPK-target of rapamycin (TOR) signaling pathway in hepatocytes in vitro. Interestingly, the findings revealed a ω-6 PUFA-induced synergistic feedback loop between autophagy and antioxidant system, which are connected with each other through the P62 and Keap1 complex. These results suggested that ω-6 PUFAs (linoleic acid) could be useful for activating a synergistic feedback loop between autophagy and antioxidant system and could greatly aid in the prevention and treatment of multiple pathologies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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