Financiado en parte por Wild Blueberry Association of North America
Improved metabolic function and cognitive performance in middle-aged adults following a single dose of wild blueberry
Whyte AR, Rahman S, Bell L, Edirisinghe I, Krikorian R, Williams CM, Burton-Freeman B
European journal of nutrition · 37 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Wild Blueberry Association of North America
Según 1 financiador declarado.
Publicación
- Publicado
- 2020-08-03 · Eur J Nutr · vol. 60 · número 3 · págs. 1521–1536
- Editorial
- Springer Science+Business Media
- Citado
- 52 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Fermentation and Sensory Analysis · Sensory Analysis and Statistical Methods
- Palabras clave
- Placebo, Meal, Effects of sleep deprivation on cognitive performance, Cognition, Audiology, Verbal learning, Medicine, Episodic memory, Triglyceride, Psychology, Internal medicine, Psychiatry, Cholesterol
- MeSH
- humans, fruit, cross-over studies, double-blind method, cognition, middle aged, child, young adult, executive function, blueberry plants
7 autores
- Adrian Robert Whyte🇬🇧University of Reading
- Sajida Rahman🇺🇸Illinois Institute of Technology
- Lynne Bell🇬🇧University of Reading
- Indika Edirisinghe🇺🇸Illinois Institute of Technology
- Robert Krikorian🇺🇸University of Cincinnati Medical Center
- Claire Michelle Williams🇬🇧 · autor de correspondenciaUniversity of Reading
- Britt Marie Burton‐Freeman🇺🇸Illinois Institute of Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Research has demonstrated cognitive benefits following acute polyphenol-rich berry consumption in children and young adults. Berry intake also has been associated with metabolic benefits. No study has yet examined cognitive performance in middle-aged adults. We investigated the relationships among cognitive and metabolic outcomes in middle-aged adults following wild blueberry (WBB) consumption.
Methods
Thirty-five individuals aged 40-65 years participated in a randomized, double blind, cross-over study. Participants consumed a breakfast meal and 1-cup equivalent WBB drink or matched placebo beverage on two occasions. Participants completed cognitive tasks and had blood drawn before and at regular intervals for 8 h after each meal/treatment. Changes in episodic memory and executive function (EF) were assessed alongside plasma levels of glucose, insulin, and triglyceride.
Results
Analysis of the memory-related Auditory Verbal Learning Task (AVLT) word recognition measure revealed a decrease in performance over the test day after placebo intake, whereas performance after WBB was maintained. For the AVLT word rejection measure, participants identified more foils following WBB in comparison to placebo. Benefits were also observed for EF on the Go/No-Go task with fewer errors following WBB intake on cognitively demanding invalid No-Go trials in comparison to placebo. Furthermore, in comparison to placebo, response times were faster for the Go/No-Go task, specifically at 4 h and 8 h following WBB treatment. We also observed reduced post-meal glucose and insulin, but not triglyceride, concentrations in comparison to placebo over the first 2 h following ingestion. Though the addition of Age, BMI, glucose and insulin as covariates to the analysis reduced the significant effect of beverage for AVLT word rejection, metabolic outcomes did not interact with treatment to predict cognitive performance with the exception of one isolated trend.
Conclusions
This study indicated acute cognitive benefits of WBB intake in cognitively healthy middle-aged individuals, particularly in the context of demanding tasks and cognitive fatigue. WBB improved glucose and insulin responses to a meal. Further research is required to elucidate the underlying mechanism by which WBB improves cognitive function.
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