Effects of L-theanine-caffeine combination on sustained attention and inhibitory control among children with ADHD: a proof-of-concept neuroimaging RCT
Kahathuduwa CN, Wakefield S, West BD, Blume J, Dassanayake TL, Weerasinghe VS, Mastergeorge A
Scientific reports · 28 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Texas Tech University
- Universidad u hospital
- Texas Tech University Health Sciences Center - School of Health Professions
- Universidad u hospital
- Texas Tech Neuroimaging Institute
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-08-04 · Sci Rep · vol. 10 · número 1 · pág. 13072
- Editorial
- Nature Portfolio
- Citado
- 43 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 87 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Attention Deficit Hyperactivity Disorder · Coffee research and impacts · Neurotransmitter Receptor Influence on Behavior
- Palabras clave
- theanine, caffeine, attention deficit hyperactivity disorder, sustained attention, inhibitory control, children, go/no-go task, stop-signal task, default mode network, mind wandering, cognitive performance, neuroimaging
- MeSH
- brain, humans, caffeine, glutamates, magnetic resonance imaging, cognition, attention, attention deficit disorder with hyperactivity, drug interactions, adolescent, child, female, male, neuroimaging, inhibition, psychological
7 autores
- Chanaka Nadeeshan Kahathuduwa🇺🇸 · autor de correspondenciaTexas Tech University; Texas Tech University Health Sciences Center
- Sarah Mallard Wakefield🇺🇸Texas Tech University; Texas Tech University Health Sciences Center
- Blake D. West🇺🇸Texas Tech University
- Jessica Blume🇺🇸Texas Tech University
- Tharaka L. Dassanayake🇱🇰🇦🇺University of Peradeniya; University of Newcastle Australia
- Vajira Senaka Weerasinghe🇱🇰University of Peradeniya
- Ann M. Mastergeorge🇺🇸Texas Tech University
Resumen
El texto original del estudio, en el idioma en que se publicó.
We examined the acute effects of L-theanine, caffeine and their combination on sustained attention, inhibitory control and overall cognition in boys with attention deficit hyperactivity disorder (ADHD). L-Theanine (2.5 mg/kg), caffeine (2.0 mg/kg), their combination and a placebo were administered in a randomized four-way repeated-measures crossover with washout, to five boys (8-15 years) with ADHD. Functional magnetic resonance imaging (fMRI) was performed during a Go/NoGo task and a Stop-signal task ~ 1 h post-dose. NIH Cognition Toolbox was administered ~ 2 h post-dose. Treatment vs. placebo effects were examined in multi-level mixed-effects models. L-Theanine improved total cognition composite in NIH Cognition Toolbox (p = 0.040) vs. placebo. Caffeine worsened and L-theanine had a trend of worsening inhibitory control (i.e. increased Stop-signal reaction time; p = 0.031 and p = 0.053 respectively). L-Theanine-caffeine combination improved total cognition composite (p = 0.041), d-prime in the Go/NoGo task (p = 0.033) and showed a trend of improvement of inhibitory control (p = 0.080). L-Theanine-caffeine combination was associated with decreased task-related reactivity of a brain network associated with mind wandering (i.e. default mode network). L-Theanine-caffeine combination may be a potential therapeutic option for ADHD-associated impairments in sustained attention, inhibitory control and overall cognitive performance.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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