Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography
Khandouzi N, Zahedmehr A, Nasrollahzadeh J
Lipids in health and disease · 11 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shahid Beheshti University of Medical Sciences
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-08-14 · Lipids Health Dis · vol. 19 · número 1 · pág. 183
- Editorial
- BioMed Central
- Citado
- 14 citas · más que el 76% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Lipoproteins and Cardiovascular Health
- Palabras clave
- olive oil, canola oil, vegetable oil consumption, lipoprotein-associated phospholipase A2, interleukin-6, inflammatory cytokines, plasma lipids, cardiovascular risk factors, coronary angiography, cardioprotection, dyslipidemia, hypertension, diabetes mellitus
- MeSH
- humans, inflammation, 1-alkyl-2-acetylglycerophosphocholine esterase, lipids, cardiotonic agents, interleukin-6, cytokines, coronary angiography, middle aged, female, male, biomarkers, olive oil, rapeseed oil
3 autores
- Nafiseh Khandouzi🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Ali Zahedmehr🇮🇷Iran University of Medical Sciences; Shaheed Rajaei Cardiovascular Medical and Research Center
- Javad Nasrollahzadeh🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity in patients undergoing coronary angiography.
Methods
The current randomized, controlled, parallel-arm, clinical trial involved 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred for coronary angiography. Patients were randomly divided into two groups and received 25 mL/day refined olive oil (n = 24) or canola oil (n = 24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA2 levels were measured at baseline and after the intervention.
Results
CO consumption produced a significant reduction in plasma Lp-PLA2 mass (- 0.97 ± 1.84 vs. 0.34 ± 1.57 ng/mL, p = 0.008 for CO and OO, respectively), whereas the mean changes in interleukine-6 concentration were significantly lower after OO consumption compared with CO (- 9.46 ± 9.46 vs. -0.90 ± 6.80 pg/mL, p = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA2 activity, complement C3, C4, or lipid profiles in the two intervention groups.
Conclusions
Comparing the two vegetable oils in subjects with cardiovascular risk factors showed that the consumption of olive oil is more effective in reducing the level of inflammatory cytokine interleukine-6, whereas canola oil was more effective in lowering Lp-PLA2 levels; however, this finding should be interpreted with caution, because Lp-PLA2 activity did not change significantly.
Trial registration
IRCT20160702028742N5 at www.irct.ir (04/19/2019).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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