Genetic susceptibility, dietary cholesterol intake, and plasma cholesterol levels in a Chinese population
Huo S, Sun L, Zong G, Song B, Zheng H, Jin Q, Li H, Lin X
Journal of lipid research · 6 citas
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Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Chinese Academy of Sciences
- Gobierno
- Ministry of Science and Technology of the People's Republic of China
- Gobierno
- Science and Technology Commission of Shanghai Municipality
- Gobierno
- Shanghai Municipal Science and Technology
- Gobierno
- Ministry of Science and Technology of China
- Universidad u hospital
- Strategic Priority Research Program of the Chinese Academy of Sciences
- Subvenciones
- Chinese Academy of Sciences (ZDBS-SSW-DQC-02); Chinese Academy of Sciences (2017SHZDZX01); National Natural Science Foundation of China (KJZD-EW-L14-2-2); National Natural Science Foundation of China (KSCX2-EW-R-10); National Natural Science Foundation of China (81700700); Chinese Academy of Sciences (KJZD-EW-L14-2-2); Ministry of Science and Technology of the People's Republic of China (2017YFC0909701); National Natural Science Foundation of China (KJZD-EW-L14); National Natural Science Foundation of China (81970684); Chinese Academy of Sciences (XDB38010300); Science and Technology Commission of Shanghai Municipality (2017SHZDZX01); National Natural Science Foundation of China (2017SHZDZX01); Chinese Academy of Sciences (KJZD-EW-L14); Ministry of Science and Technology of the People's Republic of China (2016YFC1304903); Chinese Academy of Sciences (KSCX2-EW-R-10)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2020-08-12 · J Lipid Res · vol. 61 · número 11 · págs. 1504–1511
- Editorial
- Elsevier BV
- Citado
- 7 citas · más que el 67% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Genetic Associations and Epidemiology · Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health
- Palabras clave
- Cholesterol, Quartile, Single-nucleotide polymorphism, Population, Internal medicine, Dietary Cholesterol, Endocrinology, Biology, Medicine, Genotype, Genetics, Gene, Environmental health, Confidence interval
- MeSH
- humans, cholesterol, cholesterol, dietary, risk factors, aged, middle aged, female, male, cholesterol, ldl, genetic variation, asian people
8 autores
- Shaofeng Huo🇨🇳Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Liang Tso Sun🇨🇳Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Geng Zong🇨🇳Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Boyu Song🇨🇳Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- He Zheng🇨🇳Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Qianlu Jin🇨🇳Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Huaixing Li🇨🇳 · autor de correspondenciaShanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
- Lin Xu🇨🇳 · autor de correspondenciaShanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Accompanied with nutrition transition, non-HDL-C levels of individuals in Asian countries has increased rapidly, which has caused the global epicenter of nonoptimal cholesterol to shift from Western countries to Asian countries. Thus, it is critical to underline major genetic and dietary determinants. In the current study of 2,330 Chinese individuals, genetic risk scores (GRSs) were calculated for total cholesterol (TC; GRSTC, 57 SNPs), LDL-C (GRSLDL-C, 45 SNPs), and HDL-C (GRSHDL-C, 65 SNPs) based on SNPs from the Global Lipid Genetics Consortium study. Cholesterol intake was estimated by a 74-item food-frequency questionnaire. Associations of dietary cholesterol intake with plasma TC and LDL-C strengthened across quartiles of the GRSTC (effect sizes: -0.29, 0.34, 2.45, and 6.47; Pinteraction = 0.002) and GRSLDL-C (effect sizes: -1.35, 0.17, 5.45, and 6.07; Pinteraction = 0.001), respectively. Similar interactions with non-HDL-C were observed between dietary cholesterol and GRSTC (Pinteraction = 0.001) and GRSLDL-C (Pinteraction = 0.004). The adverse effects of GRSTC on TC (effect sizes across dietary cholesterol quartiles: 0.51, 0.82, 1.21, and 1.31; Pinteraction = 0.023) and GRSLDL-C on LDL-C (effect sizes across dietary cholesterol quartiles: 0.66, 0.52, 1.12, and 1.56; Pinteraction = 0.020) were more profound in those having higher cholesterol intake compared with those with lower intake. Our findings suggest significant interactions between genetic susceptibility and dietary cholesterol intake on plasma cholesterol profiles in a Chinese population.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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