Effect of diurnal intermittent fasting during Ramadan on ghrelin, leptin, melatonin, and cortisol levels among overweight and obese subjects: A prospective observational study
Al-Rawi N, Madkour M, Jahrami H, Salahat D, Alhasan F, BaHammam A, Al-Islam Faris M
PloS one · 78 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Sharjah
- Universidad u hospital
- American University of Sharjah
- Subvenciones
- University of Sharjah (VCRG/R1061/2016); American University of Sharjah (VCRG/R1061/2016)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-08-26 · PLoS One · vol. 15 · número 8 · pág. e0237922
- Editorial
- Public Library of Science
- Citado
- 114 citas · más que el 97% de estudios similares · 6.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 69 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Palabras clave
- Ghrelin, Leptin, Internal medicine, Melatonin, Endocrinology, Circadian rhythm, Medicine, Overweight, Hormone, Appetite, Obesity
- MeSH
- humans, obesity, melatonin, hydrocortisone, leptin, lipids, diet, fasting, prospective studies, sleep, energy intake, circadian rhythm, adult, female, male, hemodynamics, ghrelin
7 autores
- Natheer Hashim Al-Rawi🇦🇪University of Sharjah
- Mohamed Ibrahim Madkour🇦🇪University of Sharjah
- Haitham Jahrami🇧🇭Ministry of Health; Arabian Gulf University
- Dana Salahat🇦🇪University of Sharjah
- Fatima Alhasan🇦🇪University of Sharjah
- Ahmed Salem BaHammam🇸🇦King Abdulaziz City for Science and Technology; King Saud University
- MoezAlIslam E. Faris🇦🇪 · autor de correspondenciaUniversity of Sharjah
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Levels of cortisol, melatonin, ghrelin, and leptin are highly correlated with circadian rhythmicity. The levels of these hormones are affected by sleep, feeding, and general behaviors, and fluctuate with light and dark cycles. During the fasting month of Ramadan, a shift to nighttime eating is expected to affect circadian rhythm hormones and, subsequently, the levels of melatonin, cortisol, ghrelin, and leptin. The present study aimed to examine the effect of diurnal intermittent fasting (DIF) during Ramadan on daytime levels of ghrelin, leptin, melatonin, and cortisol hormones in a group of overweight and obese subjects, and to determine how anthropometric, dietary, and lifestyle changes during the month of Ramadan correlate with these hormonal changes.
Methods
Fifty-seven overweight and obese male (40) and female (17) subjects were enrolled in this study. Anthropometric measurements, dietary intake, sleep duration, and hormonal levels of serum ghrelin, leptin, melatonin, and salivary cortisol were assessed one week before the start of Ramadan fasting and after 28 days of fasting at fixed times of the day (11:00 am-1:00 pm).
Results
At the end of Ramadan, serum levels of ghrelin, melatonin, and leptin significantly (P<0.001) decreased, while salivary cortisol did not change compared to the levels assessed in the pre-fasting state.
Conclusions
DIF during Ramadan significantly altered serum levels of ghrelin, melatonin, and serum leptin. Further, male sex and anthropometric variables were the most impacting factors on the tested four hormones. Further studies are needed to assess DIF's impact on the circadian rhythmicity of overweight and obese fasting people.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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