Vitamin D status and outcomes for hospitalised older patients with COVID-19
Baktash V, Hosack T, Patel N, Shah S, Kandiah P, Van den Abbeele K, Mandal AKJ, Missouris CG
Postgraduate medical journal · 159 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-08-27 · Postgrad Med J · vol. 97 · número 1149 · págs. 442–447
- Editorial
- Oxford University Press
- Citado
- 263 citas · más que el 100% de estudios similares · 30.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · Vitamin C and Antioxidants Research
- Palabras clave
- Medicine, Vitamin D and neurology, vitamin D deficiency, Coronavirus disease 2019 (COVID-19), Internal medicine, Incidence (geometry), Prospective cohort study, Gastroenterology, Cohort study, Cohort, Disease
- MeSH
- humans, pneumonia, viral, vitamin d deficiency, vitamin d, fibrin fibrinogen degradation products, radiography, thoracic, hospitalization, geriatric assessment, severity of illness index, hospital mortality, predictive value of tests, aged, female, male, biomarkers, united kingdom, outcome assessment, health care, covid-19, sars-cov-2
8 autores
- Vadir Baktash🇬🇧Wexham Park Hospital; Frimley Health NHS Foundation Trust
- Tom Hosack🇬🇧Wexham Park Hospital; Frimley Health NHS Foundation Trust
- Nishil Zahari🇬🇧Wexham Park Hospital; Frimley Health NHS Foundation Trust
- S.I. Shah🇬🇧Wexham Park Hospital; Frimley Health NHS Foundation Trust
- Pirabakaran Kandiah🇬🇧Wexham Park Hospital; Frimley Health NHS Foundation Trust
- Koenraad Van den Abbeele🇬🇧Wexham Park Hospital; Frimley Health NHS Foundation Trust
- Amit K. J. Mandal🇬🇧Wexham Park Hospital; Frimley Health NHS Foundation Trust
- Constantinos G. Missouris🇬🇧🇨🇾 · autor de correspondenciaWexham Park Hospital; Frimley Health NHS Foundation Trust; University of Cyprus
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Older adults are more likely to be vitamin D deficient. The aim of the study was to determine whether these patients have worse outcomes with COVID-19.
Methods
We conducted a prospective cohort study between 1 March and 30 April 2020 to assess the importance of vitamin D deficiency in older patients with COVID-19. The cohort consisted of patients aged ≥65 years presenting with symptoms consistent with COVID-19 (n=105). All patients were tested for serum 25-hydroxyvitamin D (25(OH)D) levels during acute illness. Diagnosis of COVID-19 was confirmed via viral reverse transcriptase PCR swab or supporting radiological evidence. COVID-19-positive arm (n=70) was sub-divided into vitamin D-deficient (≤30 nmol/L) (n=39) and -replete groups (n=35). Subgroups were assessed for disease severity using biochemical, radiological and clinical markers. Primary outcome was in-hospital mortality. Secondary outcomes were laboratory features of cytokine storm, thoracic imaging changes and requirement of non-invasive ventilation (NIV).
Results
COVID-19-positive arm demonstrated lower median serum 25(OH)D level of 27 nmol/L (IQR=20-47 nmol/L) compared with COVID-19-negative arm, with median level of 52 nmol/L (IQR=31.5-71.5 nmol/L) (p value=0.0008). Among patients with vitamin D deficiency, there was higher peak D-dimer level (1914.00 μgFEU/L vs 1268.00 μgFEU/L) (p=0.034) and higher incidence of NIV support and high dependency unit admission (30.77% vs 9.68%) (p=0.042). No increased mortality was observed between groups.
Conclusion
Older adults with vitamin D deficiency and COVID-19 may demonstrate worse morbidity outcomes. Vitamin D status may be a useful prognosticator.
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