Canola oil compared with sesame and sesame-canola oil on glycaemic control and liver function in patients with type 2 diabetes: A three-way randomized triple-blind cross-over trial
Raeisi-Dehkordi H, Amiri M, Zimorovat A, Moghtaderi F, Zarei S, Forbes SC, Salehi-Abargouei A
Diabetes/metabolism research and reviews · 15 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-08-29 · Diabetes Metab Res Rev · vol. 37 · número 5 · pág. e3399
- Editorial
- Wiley
- Citado
- 27 citas · más que el 93% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sesame and Sesamin Research · Fatty Acid Research and Health · Diet and metabolism studies
- Palabras clave
- Medicine, Internal medicine, Insulin resistance, Type 2 diabetes, Quantitative insulin sensitivity check index, Insulin, Diabetes mellitus, Canola, Liver function, Type 2 Diabetes Mellitus, Endocrinology, Gastroenterology, Insulin sensitivity, Biology, Food science
- MeSH
- liver, humans, sesamum, diabetes mellitus, type 2, insulin resistance, sesame oil, cross-over studies, female, male, rapeseed oil, glycemic control
7 autores
- Hamidreza Raeisi‐Dehkordi🇮🇷Shahid Sadoughi University of Medical Sciences and Health Services
- Mojgan Amiri🇮🇷Shahid Sadoughi University of Medical Sciences and Health Services
- Alireza Zimorovat🇮🇷Shahid Sadoughi University of Medical Sciences and Health Services
- Fatemeh Moghtaderi🇮🇷Shahid Sadoughi University of Medical Sciences and Health Services
- Sadegh Zarei🇮🇷Rafsanjan University of Medical Sciences
- Scott C. Forbes🇨🇦Brandon University
- Amin Salehi‐Abargouei🇮🇷 · autor de correspondenciaShahid Sadoughi University of Medical Sciences and Health Services
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
This study aimed to compare the effects of sesame (SO), canola (CO), and sesame-canola (SCO: a blend) oils on glycaemic control markers and liver function enzymes in adults with type 2 diabetes.
Methods
In this randomized, triple-blind, three-way, cross-over clinical trial, participants replaced their usual oil with the intervention oils for 9 weeks. Serum fasting blood sugar, fasting serum insulin (FSI), insulin resistance (HOMA2-IR), beta-cell function (HOMA2-%B), insulin sensitivity (HOMA2-%S), quantitative insulin sensitivity check index (QUICKI), as well as serum liver function enzymes were measured at baseline and end of intervention periods.
Results
Ninety-two participants completed all treatment periods. After adjusting for confounders, all treatment oils resulted in significant improvements in FSI and HOMA2-%S (p < 0.05). SO and SCO led to favourable changes in HOMA2-IR and QUICKI (p < 0.05). Following CO and SCO, there was a significant decrease in HOMA2-%B (p < 0.05). The sex-stratified analysis revealed that FSI and HOMA2-IR were decreased after SO compared to CO in males (p = 0.024). Serum gamma-glutamyltransferase (GGT) was significantly lower following SO compared to CO in females (p = 0.02), however, the difference in change values was not significant (p = 0.058).
Conclusions
SO consumption appears to improve glycaemic control markers in males and serum GGT in females compared with CO in patients with type 2 diabetes (registration code: IRCT2016091312571N6).
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