Biomarker of dietary linoleic acid and risk for stroke: A systematic review and meta-analysis
Zhang W, Zhou F, Huang H, Mao Y, Ye D
Nutrition (Burbank, Los Angeles County, Calif.) · 7 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Science and Technology Department of Zhejiang Province
- Gobierno
- Natural Science Foundation of Zhejiang Province
Según 3 financiadores declarados.
Publicación
- Publicado
- 2020-07-25 · Nutrition · vol. 79-80 · pág. 110953
- Editorial
- Elsevier BV
- Citado
- 37 citas · más que el 35% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- Medicine, Internal medicine, Meta-analysis, Hazard ratio, Stroke (engine), Cohort study, Subgroup analysis, Observational study, Confidence interval, Cohort, Publication bias
- MeSH
- humans, linoleic acid, diet, case-control studies, stroke, biomarkers
5 autores
- Wanting Zhang🇨🇳Zhejiang Chinese Medical University
- Feixiang Zhou🇨🇳Zhejiang Chinese Medical University
- Huijun Huang🇨🇳Zhejiang Chinese Medical University
- Yingying Mao🇨🇳Zhejiang Chinese Medical University
- Ding Ye🇨🇳 · autor de correspondenciaZhejiang Chinese Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Previous observational studiíes provided conflicting findings on the relationship between linoleic acid (LA) and the risk for stroke. The aim of this study was to evaluate the association of LA levels in blood or adipose tissue samples with risk for stroke.
Methods
PubMed, Web of Science, and Embase databases were searched until February 29, 2020 to identify eligible observational studies, including cohort studies, nested case-control studies, case-cohort studies, and case-control studies, reporting the association of LA with the risk for stroke and its subtypes. We pooled hazard ratio (HR) estimates with 95% confidence intervals (CIs) and conducted heterogeneity test. Sensitivity analysis and publication bias test were also carried out.
Results
Twelve studies from 11 observational articles involving 47 836 individuals were included in the meta-analysis. We observed an inverse association between biomarkers of dietary LA and risk for total stroke (HR, 0.88; 95% CI, 0.83-0.94; P < 0.001). Meta-regression analysis suggested that ethnicity (P = 0.029) and study design (P = 0.049) contributed to between-study heterogeneity. Subgroup analysis showed that the association was statistically significant among studies conducted in white (P < 0.001) and Asian (P = 0.032) populations, and those with cohort (P = 0.001) and case-cohort design (P = 0.007). Moreover, we found that higher LA levels were associated with a reduced risk for ischemic stroke (HR, 0.87; 95% CI, 0.80-0.95; P = 0.001), although no statistically significant association was found between LA levels and the risk for hemorrhagic stroke.
Conclusions
The present study supported an inverse association of LA levels with the risk for stroke, particularly ischemic stroke. Racial disparity exists in the association between LA and the risk for stroke, which deserves further studies.
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