Music-listening regulates human microRNA expression
Nair PS, Raijas P, Ahvenainen M, Philips AK, Ukkola-Vuoti L, Järvelä I
Epigenetics · 30 citas
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- Financiación independiente
- Universidad u hospital
- Helsingin Yliopisto
- Organización sin fines de lucro
- Wellcome Trust
- Gobierno
- China Scholarship Council
- Gobierno
- Medical Research Council
- Gobierno
- Biotieteiden ja Ympäristön Tutkimuksen Toimikunta
- Organización sin fines de lucro
- Wellcome Trust Center for Human Genetics
- Universidad u hospital
- University of Helsinki
- Gobierno
- MRC Hub
- Subvenciones
- Wellcome Trust (91070); Medical Research Council (G0900747 91070); Wellcome Trust (G090074791070); Wellcome Trust (G0900747); Medical Research Council (090532/Z09/Z); Biotieteiden ja Ympäristön Tutkimuksen Toimikunta (13771); Wellcome Trust (090532); Wellcome Trust (090532/Z/09/Z); Wellcome Trust (090532/Z/09/); Wellcome Trust (090532/Z)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2020-09-01 · Epigenetics · vol. 16 · número 5 · págs. 554–566
- Editorial
- Landes Bioscience
- Citado
- 53 citas · más que el 97% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 84 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Music Therapy and Health · Neuroscience and Music Perception · Noise Effects and Management
- Palabras clave
- Biology, microRNA, Active listening, Expression (computer science), Computational biology, Cell biology, Genetics, Gene, Communication, Psychology, Computer science
- MeSH
- central nervous system, humans, micrornas, dna methylation, gene expression regulation, down-regulation, music
6 autores
- Preethy Sasidharan Nair🇫🇮University of Helsinki
- Pirre Raijas🇫🇮Etelä-Karjalan sosiaali ja terveyspiiri
- Minna Ahvenainen🇫🇮University of Helsinki
- Anju K. Philips🇫🇮University of Helsinki
- Liisa Ukkola‐Vuoti🇫🇮University of Helsinki
- Irma E. Järvelä🇫🇮 · autor de correspondenciaUniversity of Helsinki
Resumen
El texto original del estudio, en el idioma en que se publicó.
Music-listening and performance have been shown to affect human gene expression. In order to further elucidate the biological basis of the effects of music on the human body, we studied the effects of music-listening on gene regulation by sequencing microRNAs of the listeners (Music Group) and their controls (Control Group) without music exposure. We identified upregulation of six microRNAs (hsa-miR-132-3p, hsa-miR-361-5p, hsa-miR-421, hsa-miR-23a-3p, hsa-miR-23b-3p, hsa-miR-25-3p) and downregulation of two microRNAs (hsa-miR-378a-3p, hsa-miR-16-2-3p) in Music Group with high musical aptitude. Some upregulated microRNAs were reported to be responsive to neuronal activity (miR-132, miR-23a, miR-23b) and modulators of neuronal plasticity, CNS myelination, and cognitive functions like long-term potentiation and memory. miR-132 plays a critical role in regulating TAU protein levels and is important for preventing tau protein aggregation that causes Alzheimer's disease. miR-132 and DICER, upregulated after music-listening, protect dopaminergic neurons and are important for retaining striatal dopamine levels. Some of the transcriptional regulators (FOS, CREB1, JUN, EGR1, and BDNF) of the upregulated microRNAs were immediate early genes and top candidates associated with musical traits. BDNF and SNCA, co-expressed and upregulated in music-listening and music-performance, are both are activated by GATA2, which is associated with musical aptitude. Several miRNAs were associated with song-learning, singing, and seasonal plasticity networks in songbirds. We did not detect any significant changes in microRNA expressions associated with music education or low musical aptitude. Our data thereby show the importance of inherent musical aptitude for music appreciation and for eliciting the human microRNA response to music-listening.
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