Efficacy and safety of a topical moisturizer containing linoleic acid and ceramide for mild-to-moderate psoriasis vulgaris: A multicenter randomized controlled trial
Li X, Yang Q, Zheng J, Gu H, Chen K, Jin H, He C, Xu AE, Xu J, Zhang J, Yu W, Guo Z, Xiong L, Song Y, Zhang L
Dermatologic therapy · 21 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81830095); National Natural Science Foundation of China (81673056)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-09-01 · Dermatol Ther · vol. 33 · número 6 · pág. e14263
- Editorial
- Wiley
- Citado
- 33 citas · más que el 73% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Psoriasis: Treatment and Pathogenesis · Dermatology and Skin Diseases · Advancements in Transdermal Drug Delivery
- Palabras clave
- plaque psoriasis, linoleic acid, ceramide, topical moisturizers, mometasone furoate, topical corticosteroids, skin barrier repair, relapse prevention, maintenance therapy, quality of life, dry skin
- MeSH
- humans, psoriasis, ceramides, linoleic acid, treatment outcome, severity of illness index, double-blind method, quality of life, adult, china, female, male
15 autores
- Xia Li🇨🇳Shanghai Jiao Tong University; Ruijin Hospital
- Qi Yang🇨🇳Shanghai Jiao Tong University; Ruijin Hospital
- Jie Zheng🇨🇳 · autor de correspondenciaShanghai Jiao Tong University; Ruijin Hospital
- Heng Gu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Kun Chen🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Hongzhong Jin🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Chun‐Xia He🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Aie Xu🇨🇳Third People's Hospital of Hangzhou
- Jin Hua Xu🇨🇳Third People's Hospital of Hangzhou
- Junling Zhang
- Wang Yu
- Zaipei Guo🇨🇳Sichuan University; West China Hospital of Sichuan University
- Lin Xiong🇨🇳Sichuan University; West China Hospital of Sichuan University
- Yanyan Song🇨🇳Shanghai Jiao Tong University
- Lina Zhang🇨🇳Shanghai Jiao Tong University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Psoriasis is a chronic, recurrent skin disease requiring long-term management. Agents that repair the skin's barrier function are invaluable additives in topical treatments of psoriasis. This multicenter, randomized, controlled trial evaluated the efficacy and safety of a linoleic acid-ceramide-containing moisturizer (LA-Cer) for mild-to-moderate psoriasis vulgaris. We randomized 178 patients from both northern and southern regions of China into two groups: 81 patients in the control group received mometasone furoate (MF, 0.1%) cream, while MF in combination with LA-Cer was administered to 86 patients in the treatment group for 4 weeks. The LA-Cer-MF group maintained the use of moisturizer after topical glucocorticoid administration. The primary endpoint, Psoriasis Area and Severity Index 50 (PASI 50) response, revealed the superiority of LA-Cer-MF with lower relapse rates at week 8. The use of the LA-Cer-containing moisturizer as maintenance therapy resulted in a continuous improvement in the clinical state in terms of body surface area, PASI, investigators' assessment of skin dryness and desquamation, and Physician Global Assessment of Psoriasis score, and in the patients' quality of life. Thus, the LA-Cer-containing moisturizer is a promising agent to prevent and treat psoriasis as it enhances the therapeutic effect induced by topical glucocorticoids and delays relapse.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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