Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study
Ooi TC, Meramat A, Rajab NF, Shahar S, Ismail IS, Azam AA, Sharif R
Nutrients · 97 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universiti Kebangsaan Malaysia
- Gobierno
- Ministry of Education, Malaysia
- Subvenciones
- Universiti Kebangsaan Malaysia (GUP-2018)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-08-30 · Nutrients · vol. 12 · número 9 · pág. 2644
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 132 citas · más que el 97% de estudios similares · 5.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 81 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- Cognitive decline, Internal medicine, Medicine, Malondialdehyde, Cognition, Ketone bodies, Weight loss, Dementia, Physiology, Endocrinology, Oxidative stress, Gerontology, Metabolism, Disease, Obesity, Psychiatry
- MeSH
- humans, dna damage, inflammation, fasting, geriatric assessment, cohort studies, follow-up studies, feeding behavior, cognition, oxidative stress, aged, malaysia, female, male, metabolomics, cognitive dysfunction
7 autores
- Theng Choon Ooi🇲🇾National University of Malaysia
- Asheila Meramat🇲🇾Sultan Zainal Abidin University
- Nor Fadilah Rajab🇲🇾National University of Malaysia
- Suzana Shahar🇲🇾National University of Malaysia
- Intan Safinar Ismail🇲🇾Universiti Putra Malaysia
- Amalina Ahmad Azam🇲🇾Universiti Putra Malaysia
- Razinah Sharif🇲🇾 · autor de correspondenciaNational University of Malaysia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Intermittent fasting (IF) refers to various dietary regimens that cycle between a period of non-fasting and a period of total fasting. This study aimed to determine the effects of IF on cognitive function among elderly individuals who practice IF who have mild cognitive impairment (MCI). A total of 99 elderly subjects with MCI of Malay ethnicity without any terminal illness were recruited from a larger cohort study, LRGS TUA. The subjects were divided into three groups, comprising those who were regularly practicing IF (r-IF), irregularly practicing IF (i-IF), and non-fasters (n-IF). Upon 36 months of follow-up, more MCI subjects in the r-IF group reverted to successful aging with no cognitive impairment and diseases (24.3%) compared to those in i-IF (14.2%) and n-IF groups (3.7%). The r-IF group's subjects exhibited significant increment in superoxide dismutase (SOD) activity and reduction in body weight, levels of insulin, fasting blood glucose, malondialdehyde (MDA), C-reactive protein (CRP), and DNA damage. Moreover, metabolomics analysis showed that IF may modulate cognitive function via various metabolite pathways, including the synthesis and degradation of ketone bodies, butanoate metabolism, pyruvate metabolism, and glycolysis and gluconeogenesis pathways. Overall, the MCI-afflicted older adults who practiced IF regularly had better cognitive scores and reverted to better cognitive function at 36 months follow-up.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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