Semen Creatine and Creatine Kinase Activity as an Indicator of Sperm Quality
Nasrallah F, Hammami MB, Omar S, Aribia HB, Sanhaji H, Feki M
Clinical laboratory · 15 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2020-01-01 · Clin Lab · vol. 66 · número 09/2020
- Editorial
- Clinical Laboratory Publications
- Citado
- 24 citas · más que el 86% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sperm and Testicular Function · Chromium effects and bioremediation · Iron Metabolism and Disorders
- Palabras clave
- Semen, Creatine kinase, Sperm quality, Sperm, Andrology, Semen quality, Creatine, Medicine, Chemistry, Internal medicine
- MeSH
- spermatozoa, semen, humans, infertility, male, creatine, creatine kinase, sperm motility, child, male
6 autores
- Fahmi Nasrallah
- Mohamed Ali Hammami
- Souheil Omar
- Hamadi Aribia
- Haïfa Sanhaji
- Moncef Feki
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The role of creatine (Cr) and creatine kinase (CK) in sperm function remains unclear. The study aimed to assess Cr and CK in seminal plasma and test their association with sperm characteristics.
Methods
The study included 62 males with couple's infertility and 26 males who have already fathered children. Semen Cr and CK were assessed by GC-MS and spectrophotometry, respectively. Seminogram parameters were analyzed using conventional methods.
Results
Cytomorphologic analysis of sperm showed normozoospermia in 53 men (NS) and an asthenozoospermia (AS) in 35 men. Semen Cr was high with no significant difference between the two groups (791 ± 342 and 744 ± 422 µmol/L, respectively). However, semen CK activity was higher in AS group (1,360 ± 1,050 vs. 830 ± 580 U/L, p = 0.013). Semen Cr was positively related to progressive motility (r = 0.284; p = 0.010). Semen CK was negatively correlated with sperm concentration (r = -0.29; p = 0.01), progressive motility (r = -0.26; p = 0.03), and the percentage of abnormal spermatozoa (r = -0.28; p = 0.02).
Conclusions
Semen contains high amounts of Cr and increased CK activity. Low semen Cr is associated with reduced sperm motility while high CK activity is associated with poor sperm quality. The findings suggest that Cr is of importance for sperm metabolism and that Cr supplementation could be useful in males with poor quality sperm.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.