Betaine and choline status modify the effects of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults
Bozack AK, Howe CG, Hall MN, Liu X, Slavkovich V, Ilievski V, Lomax-Luu AM, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV
European journal of nutrition · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIEHS NIH HHS
- Gobierno
- National Cancer Institute and National Institute of Environmental Health Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Institute of Environmental Health Sciences (R01 ES030945); National Cancer Institute (R01 CA133595); National Institute of Environmental Health Sciences (R01 CA133595); National Institute of Environmental Health Sciences (R01 ES017875); National Center for Advancing Translational Sciences (TL1‐TR001875); National Institute of Environmental Health Sciences (P42ES010349); National Institute of Environmental Health Sciences (F31ES029019); National Institute of Environmental Health Sciences (R00ES018890); National Institute of Environmental Health Sciences (#T32ES007322); National Institute of Environmental Health Sciences (K99ES030400); National Institute of Environmental Health Sciences (P30ES009089)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2020-09-11 · Eur J Nutr · vol. 60 · número 4 · págs. 1921–1934
- Editorial
- Springer Science+Business Media
- Citado
- 15 citas · más que el 83% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Folate and B Vitamins Research · Arsenic contamination and mitigation · Heavy Metal Exposure and Toxicity
- Palabras clave
- arsenic methylation, folic acid supplementation, creatine supplementation, betaine, choline, homocysteine, guanidinoacetic acid, urinary arsenic metabolites, dimethylarsinic acid, plasma folate, nutritional status, arsenic exposure, Bangladeshi adults
- MeSH
- humans, arsenic, choline, creatine, betaine, folic acid, homocysteine, environmental exposure, methylation, dietary supplements, adult
14 autores
- Anne K. Bozack🇺🇸Columbia University; Icahn School of Medicine at Mount Sinai
- Caitlin G. Howe🇺🇸University of Southern California; Columbia University
- Megan N. Hall🇺🇸State University of New York; SUNY Downstate Health Sciences University; Columbia University
- Xinhua Liu🇺🇸Columbia University
- Vesna N. Slavkovich🇺🇸Columbia University
- Vesna Ilievski🇺🇸Columbia University
- Angela M. Lomax-Luu🇺🇸Columbia University
- Faruque Parvez🇺🇸Columbia University
- Abu B. Siddique🇺🇸Columbia University
- Hasan Shahriar🇺🇸Columbia University
- Mohammad Nasir Uddin🇺🇸Columbia University
- Tariqul Islam🇺🇸Columbia University
- Joseph H. Graziano🇺🇸Columbia University
- Mary V. Gamble🇺🇸 · autor de correspondenciaColumbia University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Methylation of ingested inorganic arsenic (InAs) to monomethyl- (MMAs) and dimethyl-arsenical species (DMAs) facilitates urinary arsenic elimination. Folate and creatine supplementation influenced arsenic methylation in a randomized controlled trial. Here, we examine if baseline status of one-carbon metabolism nutrients (folate, choline, betaine, and vitamin B12) modified the effects of FA and creatine supplementation on changes in homocysteine, guanidinoacetate (GAA), total blood arsenic, and urinary arsenic metabolite proportions and indices.
Methods
Study participants (N = 622) received 400 or 800 μg FA, 3 g creatine, 400 μg FA + 3 g creatine, or placebo daily for 12 weeks.
Results
Relative to placebo, FA supplementation was associated with greater mean increases in %DMAs among participants with betaine concentrations below the median than those with levels above the median (FDR < 0.05). 400 μg FA/day was associated with a greater decrease in homocysteine among participants with plasma folate concentrations below, compared with those above, the median (FDR < 0.03). Creatine treatment was associated with a significant decrease in %MMAs among participants with choline concentrations below the median (P = 0.04), but not among participants above the median (P = 0.94); this effect did not significantly differ between strata (P = 0.10).
Conclusions
Effects of FA and creatine supplementation on arsenic methylation capacity were greater among individuals with low betaine and choline status, respectively. The efficacy of FA and creatine interventions to facilitate arsenic methylation may be modified by choline and betaine nutritional status.
Clinical trial registration
Clinical Trial Registry Identifier: NCT01050556, U.S. National Library of Medicine, https://clinicaltrials.gov ; registered January 15, 2010.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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